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[CAS NO. 676128-63-5] RSV604
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-12993 |
| Brand: | MCE |
| CAS: | 676128-63-5 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 388.39 |
| Molecular Formula | C22H17FN4O2 |
| SMILES | O=C1[C@@H](NC(NC2=C(F)C=CC=C2)=O)N=C(C3=CC=CC=C3)C4=CC=CC=C4N1 |
2 Publications Citing Use of MCE
Summary
IC50 & Target
Kd: 1.6 μM (nucleocapsid protein) [2]
In Vitro
RSV604 (5 days) inhibits the growth of four laboratory strains of RSV (RSS, Long, A2 and B), with EC
50
s ranging from 0.5 to 0.9 μM in plaque reduction assay
[1]
.
RSV604 (6 days) inhibits RSV-induced HEp-2 cell death, with an EC
50
of 0.86 μM
[1]
.
RSV604 (3 days) reduces viral antigen synthesis in RSV-infected HEp-2 cells, with an EC
50
of 1.7 μM
[1]
.
RSV604 (1-20 μM; 7 days) dose-dependently inhibits RSV infection in human airway epithelial (HAE) cells, with no gross cytotoxicity, leakage of basolateral fluid to the apical surface, or alteration of cilium beat frequency
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT00416442 | Novartis Pharmaceuticals|Novartis |
Healthy
|
October 2006 | Phase 1 |
| NCT00232635 | Arrow Therapeutics |
Respiratory Syncytial Virus Infections
|
September 2005 | Phase 2 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 257.47 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5747 mL | 12.8737 mL | 25.7473 mL |
| 5 mM | 0.5149 mL | 2.5747 mL | 5.1495 mL |
| 10 mM | 0.2575 mL | 1.2874 mL | 2.5747 mL |
References
Synonyms
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