[CAS NO. 67920-52-9] (Rac)-Salvianic acid A sodium
PRODUCTS SPECIFICATIONS [67920-52-9]
DESCRIPTION [67920-52-9]
Overview
| MDL | MFCD07781415 |
|---|---|
| Molecular Weight | 220.15 |
| Molecular Formula | C9H9NaO5 |
| SMILES | OC1=C(O)C=CC(CC(C(O[Na])=O)O)=C1 |
Summary
Danshensu (sodium salt) is odium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced vasoconstriction in Ca2+-free medium. In vitro: Sodium danshensu showed a biphasic effects on vessel tension. While low dosage of sodium danshensu produced small contraction possibly through transient enhancement of Ca2+ influx, high dosage produced significant vasodilation mainly through promoting the opening of non-selective K+ channels and small-conductance calcium-sensitive K+ channels in the vascular smooth muscle cells.[1]In vivo: Danshensu did not change the expression of AGEs but partly blocked the increased expression of RAGE in the hippocampus of diabetic mice. Danshensu could ameliorate the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation.[2]
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 100 mg/mL ( 454.24 mM ; Need ultrasonic)
DMSO : 100 mg/mL ( 454.24 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.5424 mL | 22.7118 mL | 45.4236 mL |
| 5 mM | 0.9085 mL | 4.5424 mL | 9.0847 mL |
| 10 mM | 0.4542 mL | 2.2712 mL | 4.5424 mL |
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1.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (227.12 mM); Clear solution; Need ultrasonic
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2.
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3.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (11.36 mM); Clear solution
References
- [1] Zhang N. Biphasic effects of sodium danshensu on vessel function in isolated rat aorta. Acta Pharmacol Sin, 2010 Apr, 31(4):421-8.
- [2] Tian Wang et al. Danshensu ameliorates the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation. J Neuroimmunol, 2012 Apr, 245(1-2):79-86.