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[CAS NO. 681159-27-3] CBR-5884
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-100012 |
| Brand: | MCE |
| CAS: | 681159-27-3 |
Overview
| MDL | MFCD04451442 |
|---|---|
| Molecular Weight | 336.39 |
| Molecular Formula | C14H12N2O4S2 |
| SMILES | O=C(C1=C(C)C(SC#N)=C(NC(C2=CC=CO2)=O)S1)OCC |
13 Publications Citing Use of MCE
- [1]Immunity. 2021 Aug 10;54(8):1728-1744.e7.
- [2]Cell Metab. 2021 May 4;33(5):971-987.e6.
- [3]Mol Cell. 2019 Sep 19;75(6):1147-1160.e5.
- [4]Sci Adv. 2022 Dec 16;8(50):eabm7902.
- [5]Nat Commun. 2022 May 16;13(1):2699.
- [6]Nat Commun. 2019 Jun 20;10(1):2701.
- [7]J Clin Invest. 2020 Jun 1;130(6):3253-3269.
- [8]Cell Mol Immunol. 2022 Nov;19(11):1263-1278.
- [9]Sci Signal. 2022 Feb 15;15(721):eabi9983.
- [10]Front Cell Dev Biol. 2021 May 12;9:639111.
- [11]Oxid Med Cell Longev. 05 Sept 2022.
- [12]Onco Targets Ther. 2020 May 29;13:4833-4842.
- [13]Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338221145994.
Summary
CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC 50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis [1] .
IC50 & Target
PHGDH, serine synthesis [1]
In Vitro
CBR-5884 (15 or 30 μM; 3-5 days) selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay [1]
| Cell Line: | Breast and melanoma cell lines |
| Concentration: | 15 or 30 μM |
| Incubation Time: | 3-5 days |
| Result: | Inhibited the proliferation of melanoma and breast cancer lines. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 148.64 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9727 mL | 14.8637 mL | 29.7274 mL |
| 5 mM | 0.5945 mL | 2.9727 mL | 5.9455 mL |
| 10 mM | 0.2973 mL | 1.4864 mL | 2.9727 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (6.18 mM); Clear solution
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