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[CAS NO. 6894-43-5] Kahweol
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-N6258 |
| Brand: | MCE |
| CAS: | 6894-43-5 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 314.42 |
| Molecular Formula | C20H26O3 |
| SMILES | C[C@]12[C@@]3([H])[C@@]4(CC[C@]1([H])C5=C(OC=C5)C=C2)C[C@@]([C@](CO)(O)C4)([H])CC3 |
Summary
IC50 & Target
AMPK; adipogenesis; apoptosis [1]
In Vitro
Kahweol (20-40 μM; 24 hours) decreases TGF-β-induced CTGF protein expression in AML12 and LX2 cells
[1]
.
Kahweol (20-40 μM; 1 hour) decreases TGF-β-induced phospho-Smad2/3 expression in AML12 cells, but does not affect expression in LX2 cells
[1]
.
Kahweol (20-40 μM) significantly decreased TGF-β-stimulated phospho-ERK and JNK expression in primary hepatocytes only
[1]
.
kahweol (0-25 μg/ml; 6-24 hours) increased the phosphorylation of AMPK and its downstream target Acetyl-CoA carboxylase (ACC) in a time-dependent manner in 3T3-L1 cells
[2]
.
kahweol (0-25 μg/ml) significantly affects protein expression of PPARγ, C/EBPα, FABP4, and FASN, that regulate adipocyte differentiation and lipid metabolism
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [2]
| Cell Line: | 3T3-L1 cells |
| Concentration: | 0, 5, 10, 25 μg/ml |
| Incubation Time: | |
| Result: | Reduced PPARγ, C/EBPα, FABP4, and FASN expression in a dose-dependent manner. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 33.33 mg/mL ( 106.00 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.1805 mL | 15.9023 mL | 31.8046 mL |
| 5 mM | 0.6361 mL | 3.1805 mL | 6.3609 mL |
| 10 mM | 0.3180 mL | 1.5902 mL | 3.1805 mL |
References
- [1] Seo HY, et al. Kahweol decreases hepatic fibrosis by inhibiting the expression of connective tissue growth factor via the transforming growth factor-beta signaling pathway. Oncotarget. 2017 Aug 1;8(50):87086-87094.
- [2] Baek JH, et al. Kahweol inhibits lipid accumulation and induces Glucose-uptake through activation of AMP-activated protein kinase (AMPK). BMB Rep. 2017 Nov;50(11):566-571.
Synonyms
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