[CAS NO. 69123-90-6] Fiacitabine

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PRODUCTS SPECIFICATIONS [69123-90-6]

Catalog

HY-50735

Brand

MCE

CAS

69123-90-6

DESCRIPTION [69123-90-6]

Overview

MDL	MFCD00868897
Molecular Weight	371.10
Molecular Formula	C9H11FIN3O4
SMILES	O=C(N=C1N)N([C@@H]([C@H]([C@@H]2O)F)O[C@@H]2CO)C=C1I

For research use only. We do not sell to patients.

Summary

Fiacitabine(NSC 382097; FIAC; FOAC) is a selective inhibitior of DNA replication of herpes simplex virus(HSV) with IC50 values of 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively. IC50 value: 2.5/12.6 nM (HSV1/2) [2] Target: HSV FIAC suppressed by 90% the replication of various strains of herpes simplex virus types 1 and 2 at concentrations of 0.0025 to 0.0126 microM. Cytotoxicity was minimal, as determined by trypan blue dye exclusion with norman Vero, WI-38, and NC-37 cell proliferation; the 50% inhibitory dose was 4 to 10 microM in a 4-day assay. FIAC was active at much lower concentrations than arabinosylcytosine, iododeoxyuridine, and arabinosyladenine. It was slightly more active against herpes simplex virus type 1 than acycloquanosine and slightly more toxic to normal cells. FIAC was about 8,000 times more active against the replication of wild-type herpes simplex virus type 1 than against a mutant strain lacking the expression of virus-specified thymidine kinase [2].

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00000981	National Institute of Allergy and Infectious Diseases (NIAID)\|Oclassen Pharmaceuticals	Cytomegalovirus Infections\|HIV Infections		Phase 2

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 37 mg/mL ( 99.70 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6947 mL	13.4735 mL	26.9469 mL
5 mM	0.5389 mL	2.6947 mL	5.3894 mL
10 mM	0.2695 mL	1.3473 mL	2.6947 mL

* Please refer to the solubility information to select the appropriate solvent.

References

Synonyms

2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-

4-Amino-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-2(1H)-pyrimidinone

1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine

1-β-D-2′-Fluoroarabino-5-iodocytosine

2′-Fluoro-5-iodo-1-β-D-arabinofuranosylcytosine

FIAC

Fiacitabine

FOAC

NSC 382097