[CAS NO. 69123-98-4] Fialuridine

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PRODUCTS SPECIFICATIONS [69123-98-4]

Catalog

HY-118122

Brand

MCE

CAS

69123-98-4

DESCRIPTION [69123-98-4]

Overview

MDL	MFCD00866922
Molecular Weight	372.09
Molecular Formula	C9H10FIN2O5
SMILES	O[C@H]1[C@H](F)[C@H](N2C(NC(C(I)=C2)=O)=O)O[C@@H]1CO

For research use only. We do not sell to patients.

Summary

Fialuridine is a nucleoside analog with antiviral activity ^[1] . Fialuridine shows anti-orthopoxvirus activity.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00000654	National Institute of Allergy and Infectious Diseases (NIAID)\|Oclassen Pharmaceuticals	Herpes Simplex\|HIV Infections\|Hepatitis B		Phase 2

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 268.75 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6875 mL	13.4376 mL	26.8752 mL
5 mM	0.5375 mL	2.6875 mL	5.3750 mL
10 mM	0.2688 mL	1.3438 mL	2.6875 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.72 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.72 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.72 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-

1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione

1-(2′-Deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-iodouracil

5-Iodo-2′-fluoroarauracil

1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil

FIAU

Fialuridine

Fluoroiodoarauracil

NSC 678514