[CAS NO. 691868-88-9] RO8191

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PRODUCTS SPECIFICATIONS [691868-88-9]

Catalog

HY-W063968

Brand

MCE

CAS

691868-88-9

DESCRIPTION [691868-88-9]

Overview

MDL	MFCD03102493
Molecular Weight	373.21
Molecular Formula	C14H5F6N5O
SMILES	FC(C1=C2C=CC3=NC(C4=NN=CO4)=CN3C2=NC(C(F)(F)F)=C1)(F)F

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Oncol Rep. 2022 Oct;48(4):169.

Summary

RO8191 (CDM-3008), an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNα/β receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC ₅₀ of 200 nM for HCV replicon ^[1] . RO8191 is a cccDNA modulator (CDM) through interferon-like activity and has anti- HBV activity ^[2] .

IC50 & Target

JAK1

In Vitro

RO8191 (CDM-3008) exerts antiviral activity dependent on IFNAR2/JAK1, but is independent of IFNAR1/Tyk2. RO8191, an IFNAR2 agonist, stimulates IFN signals in mice ^[1] .
RO8191 (0.08, 0.4, 2, 10 μM; for 72 h) strongly suppresses HCV replicon activity at 72 h in a dose-dependent manner. RO8191 reduces levels of the proteins HCV NS3 and NS4A, which are localized mainly in the perinuclear region of the replicon cells ^[1] .
RO8191 (0.08-10 μM; for 72 h) results in the disappearance of viral proteins such as NS3, NS4A/B, and NS5A/B ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RO8191 (CDM-3008; 30 mg/kg; oral) significantly induces antiviral genes Oas1b, Mx1, and Pkr in the livers of six-week-old C57BL/6J mice ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL ( 13.40 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6795 mL	13.3973 mL	26.7946 mL
5 mM	0.5359 mL	2.6795 mL	5.3589 mL
10 mM	0.2679 mL	1.3397 mL	2.6795 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 0.5 mg/mL (1.34 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 0.5 mg/mL (1.34 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 0.5 mg/mL (1.34 mM); Clear solution

* All of the co-solvents are available by MCE.