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[CAS NO. 691868-88-9] RO8191
| Ships within | Stock | Price | Qty | Total |
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| Catalog: | HY-W063968 |
| Brand: | MCE |
| CAS: | 691868-88-9 |
Overview
| MDL | MFCD03102493 |
|---|---|
| Molecular Weight | 373.21 |
| Molecular Formula | C14H5F6N5O |
| SMILES | FC(C1=C2C=CC3=NC(C4=NN=CO4)=CN3C2=NC(C(F)(F)F)=C1)(F)F |
1 Publications Citing Use of MCE
Summary
RO8191 (CDM-3008), an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNα/β receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC 50 of 200 nM for HCV replicon [1] . RO8191 is a cccDNA modulator (CDM) through interferon-like activity and has anti- HBV activity [2] .
IC50 & Target
|
JAK1
|
In Vitro
RO8191 (CDM-3008) exerts antiviral activity dependent on IFNAR2/JAK1, but is independent of IFNAR1/Tyk2. RO8191, an IFNAR2 agonist, stimulates IFN signals in mice
[1]
.
RO8191 (0.08, 0.4, 2, 10 μM; for 72 h) strongly suppresses HCV replicon activity at 72 h in a dose-dependent manner. RO8191 reduces levels of the proteins HCV NS3 and NS4A, which are localized mainly in the perinuclear region of the replicon cells
[1]
.
RO8191 (0.08-10 μM; for 72 h) results in the disappearance of viral proteins such as NS3, NS4A/B, and NS5A/B
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
RO8191 (CDM-3008; 30 mg/kg; oral) significantly induces antiviral genes Oas1b, Mx1, and Pkr in the livers of six-week-old C57BL/6J mice
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 5 mg/mL ( 13.40 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6795 mL | 13.3973 mL | 26.7946 mL |
| 5 mM | 0.5359 mL | 2.6795 mL | 5.3589 mL |
| 10 mM | 0.2679 mL | 1.3397 mL | 2.6795 mL |
References
- [1] Hideyuki Konishi, et al. An Orally Available, Small-Molecule Interferon Inhibits Viral Replication. Sci Rep. 2012;2:259.
- [2] Yutaka Furutani, et al. An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes. PLoS One. 2019 Jun 12;14(6):e0216139.
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