[CAS NO. 692869-38-8] ROCK1-IN-1

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PRODUCTS SPECIFICATIONS [692869-38-8]

Catalog

HY-Q22471

Brand

MCE

CAS

692869-38-8

DESCRIPTION [692869-38-8]

Overview

MDL	-
Molecular Weight	325.38
Molecular Formula	C17H15N3O2S
SMILES	O=C(NC1=NC(C2=CC=NC=C2)=CS1)CC3=CC=C(OC)C=C3

For research use only. We do not sell to patients.

Summary

ROCK1-IN-1 is a ROCK1 inhibitor with a K _i value of 540 nM. ROCK1-IN-1 can be used for the research of hypertension, glaucoma and erectile dysfunction ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 384.17 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0733 mL	15.3666 mL	30.7333 mL
5 mM	0.6147 mL	3.0733 mL	6.1467 mL
10 mM	0.3073 mL	1.5367 mL	3.0733 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Green J, et al. Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors. J Med Chem. 2015 Jun 25;58(12):5028-37.