[CAS NO. 69304-47-8] Brivudine
PRODUCTS SPECIFICATIONS [69304-47-8]
DESCRIPTION [69304-47-8]
Overview
| MDL | MFCD00058585 |
|---|---|
| Molecular Weight | 333.14 |
| Molecular Formula | C11H13BrN2O5 |
| SMILES | OC[C@@H]1[C@H](C[C@H](N2C(NC(C(/C=C/Br)=C2)=O)=O)O1)O |
1 Publications Citing Use of MCE
Summary
Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster.
In Vitro
Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir [1] . It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
At a dose of 125 mg once daily, brivudine has proved to be superior to aciclovir with respect to reducing the period of new blister production, and has shortened the duration of post-herpetic neuralgia [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT00031616 | NewBiotics|National Cancer Institute (NCI) |
Colorectal Cancer
|
December 2001 | Phase 1|Phase 2 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 200 mg/mL ( 600.35 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.0017 mL | 15.0087 mL | 30.0174 mL |
| 5 mM | 0.6003 mL | 3.0017 mL | 6.0035 mL |
| 10 mM | 0.3002 mL | 1.5009 mL | 3.0017 mL |
References
Synonyms