[CAS NO. 69563-88-8]  GI-530159

TREK (TWIK-related K) two pore domain potassium (K2P) channels regulate the excitability of somatosensory nociceptive neurons and mediate pain perception ^[1] .
GI-530159 (1 µM or 10 µM) shows selectivity and activates TREK1 and TREK2 channels but shows no significant effects on TRAAK channels or K channels tested ^[1] .
GI-530159 (0.1-30 µM) activates recombinant human TREK1 channels with EC ₅₀ s of 0.8 µM and 0.9 µM from Rb efflux and electrophysiological experiments, respectively ^[1] .
GI-530159 (1 µM) reduces rat dorsal root ganglion (DRG) neuron excitability, results in firing frequency reduction and a small hyperpolarisation of resting membrane potential (RMP) ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.