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[CAS NO. 69739-16-8] Cefodizime
| Ships within | Stock | Price | Qty | Total |
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| Catalog: | HY-108402 |
| Brand: | MCE |
| CAS: | 69739-16-8 |
Overview
| MDL | MFCD00864926 |
|---|---|
| Molecular Weight | 584.67 |
| Molecular Formula | C20H20N6O7S4 |
| SMILES | O=C(C(N12)=C(CSC3=NC(C)=C(CC(O)=O)S3)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O)O |
Summary
Cefodizime is a third generation cephalosporin antibiotic with a broad spectrum of antibacterial activity. Cefodizime has no renal toxic effect, good tolerance and immune regulation activity, and has the potential for severe infections of the respiratory and urinary tracts [1] [2] .
IC50 & Target
Bacterial [1]
In Vitro
Enterobacteriaceae including
Escherichia coli
,
Klebsiella pneumoniae
,
Morganella morgan ii
,
Proteus mirabilis
,
Proteus vulgaris
,
Shigella sonnei
,
Yersinia enterocolitica
and
Salmonella
species are all consistently sensitive to Cefodizime in vitro. Cefodizime has marginal but variable inhibitory activity against
Citrobacter
species including
Citrobacter freundii
, and
Serratia marcescens
. Cefodizime inhibits other Gram-negative bacteria including
Haemophilus irifluenzae
,
Moraxella catarrhalis
,
Neisseria gonorrhoeae
and
Neisseria meningitidis
[1]
.
Cefodizime is a bactericidal antibiotic having high affinity for penicillin-binding proteins lA/B, 2 and 3 of
E. coli
. The in vitro concentrations of Cefodizime resulting in bactericidal activity against susceptible strains of Gram-positive and Gram-negative bacteria are generally similar to the minimum inhibitory concentrations
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
In experimentally-induced K. pneumoniae respiratory tract infections in mice, Cefodizime has activity comparable to Cefotaxime and Ceftazidime, and greater than that of Cefoperazone, Latamoxef, Cefuroxime or cefazolin for 8 hours after a single subcutaneous dose of 50 mg/kg. However, unlike these cephalosporins, Cefodizime continues to demonstrate pronounced bactericidal activity for at least 48 hours after a single injection. Complete bacterial clearance from the lung is achieved within 48 hours in 50% of the mice although Cefodizime is no longer detectable in the serum [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 20.83 mg/mL ( 35.63 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.7104 mL | 8.5518 mL | 17.1037 mL |
| 5 mM | 0.3421 mL | 1.7104 mL | 3.4207 mL |
| 10 mM | 0.1710 mL | 0.8552 mL | 1.7104 mL |
References
- [1] Barradell LB, et al. Cefodizime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1992 Nov;44(5):800-34.
- [2] Hu T, et al. Probing the interaction of cefodizime with human serum albumin using multi-spectroscopic and molecular docking techniques. J Pharm Biomed Anal. 2015 Mar 25;107:325-32.
Synonyms
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