[CAS NO. 698346-43-9] 84-B10
PRODUCTS SPECIFICATIONS [698346-43-9]
DESCRIPTION [698346-43-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 473.44 |
| Molecular Formula | C25H22F3NO5 |
| SMILES | O=C(O)CC(CC(NC1=CC(C(F)(F)F)=CC=C1OC2=CC=C(OC)C=C2)=O)C3=CC=CC=C3 |
Summary
84-B10 is a 3-phenylglutaric acid derivative. 84-B10 inhibits cisplatin (HY-17394) induced tubular ferroptosis . 84-B10 attenuates cisplatin-induced mitochondrial damage and oxidative stress. 84-B10 ameliorates cisplatin-induced acute kidney injury (AKI) [1] .
In Vitro
84-B10 (10-100 μM; 2 h) inhibits cisplatin-induced tubular epithelial cell ferroptosis in a dose-dependent manner
[1]
.
84-B10 (40 μM; 2 h; TKPT cells) restores cisplatin-induced mitochondrial structural damage and dysfunction
[1]
.
84-B10 (40 μM; 2 h; TKPT cells) attenuates mtROS-induced oxidative stress in cisplatin-induced AKI
[1]
.
84-B10 (40 μM; 2 h; TKPT cells) attenuates cisplatin-induced epithelial cell injury by eliminating mtROS and restoring mitochondrial homeostasis
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [1]
| Cell Line: | tubular epithelial cell |
| Concentration: | 10, 20, 30, 40, 50, and 100 μM |
| Incubation Time: | 2 hours |
| Result: | Increased the levels of NRF2, SLC7A11, and GPX4 in a dose-dependent manner. |
Western Blot Analysis [1]
| Cell Line: | TKPT cells |
| Concentration: | 40 μM |
| Incubation Time: | 2 hours |
| Result: | Increased the levels of OM Porins, IMS Cyt c, IM CVa, IM Core 1, and Matrix CypD in a dose-dependent manner. |
In Vivo
84-B10 (5-15 mg/kg; i.p.) alleviates cisplatin-induced acute kidney injury in mice [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male C57BL/6 mice with acute kidney injury [1] |
| Dosage: | 5, 10, and 15 mg/kg |
| Administration: | intraperitoneal injection |
| Result: |
Decreased the sCr and BUN levels of cisplatin-exposed mice.
Attenuated renal tubules morphological abnormalities in a dose-dependent manner. Decreased NGAL and KIM-1 levels in a dose-dependent manner. Decreased the transcription levels of Lcn2 (which encodes NGAL) and Havcr1. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.