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[CAS NO. 702662-50-8] STINGagonist-1
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-19711 |
| Brand: | MCE |
| CAS: | 702662-50-8 |
Overview
| MDL | MFCD04062826 |
|---|---|
| Molecular Weight | 430.88 |
| Molecular Formula | C21H16ClFN2O3S |
| SMILES | O=C(C1=CC=C(SCC(N2CC3=C(F)C=CC=C3Cl)=O)C2=C1)NCC4=CC=CO4 |
1 Publications Citing Use of MCE
Summary
IC50 & Target
IC90: 24.57 μM (VEEV) [1]
In Vitro
G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts
[1]
.
G10 is an indirect activator of human STING-dependent phenotypes
[1]
.
G10-mediated IRF3 activation and anti-Alphaviral activity occur independently of IPS-1/MAVS-dependent signaling
[1]
.
STING is required for G10-mediated IRF3 activation, gene expression, and anti-Alphaviral activity
[1]
.
G10 induces STING-dependent synthesis and secretion of bioactive interferon
[1]
.
G10 induces innate antiviral mRNA expression in primary human cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT03753022 | Federal University of São Paulo|Vanessa Marques Ferreira |
Coronary Artery Disease|Coronary Artery Bypass Grafting|Acute Lung Injury
|
January 2012 | Not Applicable |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 75 mg/mL ( 174.06 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3208 mL | 11.6042 mL | 23.2083 mL |
| 5 mM | 0.4642 mL | 2.3208 mL | 4.6417 mL |
| 10 mM | 0.2321 mL | 1.1604 mL | 2.3208 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.80 mM); Clear solution
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