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[CAS NO. 70375-43-8] SCH-202676
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-133862 |
| Brand: | MCE |
| CAS: | 70375-43-8 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 267.35 |
| Molecular Formula | C15H13N3S |
| SMILES | C/N=C1N=C(C2=CC=CC=C2)N(C3=CC=CC=C3)S/1 |
Summary
SCH-202676 is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR) . SCH-202676 has antiviral activity and inhibits 3CL pro in a time-dependent manner with an IC 50 value of 0.655 µM [1] [2] [3] [4] .
IC50 & Target
|
Adenosine A 3 receptor
|
In Vitro
SCH-202676 (compound 6a) (0.01, 0.1, 1 and 10 µM; 0, 5, 10 and 20 min) shows antiviral activity and inhibits 3CL
pro
in a time-dependent manner, with IC
50
values of 0.409, 0.302, 0.206 and 0.191 µM for 0, 5, 10 and 20 min, respectively
[1]
.
SCH-202676 (10 μM; 90 min) enhances the labelling of [
35
S]GTPγS in rat forebrain membranes
[2]
.
SCH-202676 inhibits the agonist [
3
H]UK-14,304 (HY-B0659) and the antagonist [
3
H] Yohimbine (HY-12715) binding to the α
2a
adrenergic receptor
[3]
.
SCH-202676 (10 μM) selectively accelerates agonist dissociation at adenosine A3 receptors, slows antagonist dissociation at adenosine Ai receptors or accelerates antagonist dissociation at adenosine AzA receptors
[4]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Ren P, et al. Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2. Eur J Med Chem. 2023 Jan 18;249:115129.
- [2] Lewandowicz AM, et al. The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br J Pharmacol. 2006 Feb;147(4):422-9.
- [3] Fawzi A B, et al. SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors[J]. Molecular Pharmacology, 2001, 59(1): 30-37.
- [4] Gao ZG, et al. Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors. Life Sci. 2004 May 7;74(25):3173-80.
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