[CAS NO. 713492-66-1] Mcl1-IN-1
PRODUCTS SPECIFICATIONS [713492-66-1]
DESCRIPTION [713492-66-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 435.86 |
| Molecular Formula | C23H18ClN3O4 |
| SMILES | O=C(O)COC1=CC=CC=C1C(NC2=NC=CC=C2)C3=C(O)C4=NC=CC=C4C(Cl)=C3 |
Summary
Mcl1-IN-1 is an inhibitor of myeloid cell factor 1 ( Mcl-1 ) ( IC 50 =2.4 µM).
IC50 & Target
|
Mcl-1 2.4 μM (IC 50 ) |
In Vitro
Mcl1-IN-1 (Compound 1) is a Mcl-1 inhibitor, which demonstrates good Mcl-1 inhibition (IC 50 =2.4 µM) with no appreciable inhibition of Bcl-xL at 100 µM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 50 mg/mL ( 114.72 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.2943 mL | 11.4716 mL | 22.9431 mL |
| 5 mM | 0.4589 mL | 2.2943 mL | 4.5886 mL |
| 10 mM | 0.2294 mL | 1.1472 mL | 2.2943 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.74 mM); Clear solution