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[CAS NO. 7177-50-6] Nafcillin sodium monohydrate
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-B0555A |
| Brand: | MCE |
| CAS: | 7177-50-6 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 454.47 |
| Molecular Formula | C21H23N2NaO6S |
| SMILES | O=C([C@@H]1N(C2=O)[C@]([C@@H]2NC(C(C3=CC=CC=C3C=C4)=C4OCC)=O)([H])SC1(C)C)O[Na].O |
2 Publications Citing Use of MCE
Summary
Nafcillin sodium monohydrate, an antibiotic , is a reversible inhibitor of β-lactamase . Nafcillin sodium monohydrate can be used for the research of staphylococcal infections [1] [2] .
IC50 & Target
Bacteria [1]
In Vivo
Nafcillin sodium monohydrate (100 mg/kg; s.c.) exhibits bactericidal activity against methicillin-susceptible
Staphylococcus aureus
(MSSA) and methicillin-resistant
S. aureus
(MRSA), with
MIC
s of 0.5 μg/mL and 64.0 μg/mL for
S. aureus
strains Xen-29 and Xen-1, respectively, in mice
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | CD-1 female mice (20-25 g), with MRSA- and MSSA-infected [3] |
| Dosage: | 100 mg/kg |
| Administration: | Subcutaneous injection |
| Result: | Protected 100% of the healthy mice with MSSA infections. |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT00428844 | Cubist Pharmaceuticals LLC |
Osteomyelitis
|
June 26, 2007 | Phase 2 |
| NCT04775953 | National Institute of Allergy and Infectious Diseases (NIAID) |
Staphylococcal Bacteraemia
|
April 22, 2021 | Phase 2 |
| NCT01922011 | Cubist Pharmaceuticals LLC |
Acute Hematogenous Osteomyelitis
|
September 13, 2013 | Phase 3 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL ( 220.04 mM ; Need ultrasonic)
H 2 O : 1 mg/mL ( 2.20 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.2004 mL | 11.0018 mL | 22.0037 mL |
| 5 mM | 0.4401 mL | 2.2004 mL | 4.4007 mL |
| 10 mM | 0.2200 mL | 1.1002 mL | 2.2004 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (220.04 mM); Clear solution; Need ultrasonic
-
2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (5.50 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.50 mM); Clear solution
References
- [1] Tan, A.K., et al. Identification of the site of covalent attachment of nafcillin, a reversible suicide inhibitor of beta-lactamase. Biochem J, 1992. 281 ( Pt 1): p. 191-6.
- [2] Palmer, D.L., et al. Bacterial wound colonization after broad-spectrum versus narrow-spectrum antibiotics. Ann Thorac Surg, 1995. 59(3): p. 626-31.
- [3] Lawrence I. Mortin, et al. Rapid Bactericidal Activity of Daptomycin against Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Peritonitis in Mice as Measured with Bioluminescent Bacteria. Antimicrob Agents Chemother. 2007 May; 51(5): 1787-1794.
Synonyms
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