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[CAS NO. 722494-26-0] BpV(HOpic)
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-128693 |
| Brand: | MCE |
| CAS: | 722494-26-0 |
Overview
| MDL | MFCD01862576 |
|---|---|
| Molecular Weight | 347.24 |
| Molecular Formula | C6H4K2NO8V |
| SMILES | O=[V+3]12([O-]3)([O-][O-]1)([O-][O-]2)[N]4=CC(O)=CC=C4C3=O.[2 K+] |
2 Publications Citing Use of MCE
Summary
IC50 & Target
IC50: 14 nM (PTEN) [1]
In Vitro
BpV(HOpic) (1 µM) treatment increases cell proliferation and decreases apoptotic rate in MG63 cells received Cisplatin treatment
[3]
.
Bpv(HOpic) (1 µM) enhances migration of C2C12 myoblasts and is associated with activation of PI3K/AKT and MAPK/ERK signalling pathways
[4]
.
BpV(HOpic) (1 µM; 48 hours) promotes the initiation of swine follicle growth and development, similar as in rodent species and humans
[5]
.
Nanocarrier-BpV(HOpic) enhances axonal outgrowth of neurons
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
BpV(HOpic) (0.05 mg/kg; i.p.) at reperfusion ameliorates liver ischemia/reperfusion (I/R) injury in vivo
[6]
.
BpV(HOpic) (200 μg/kg; i.p.) exacerbates renal dysfunction and promotes tubular damage in mice with ischemia/reperfusion injury (IRI)
[7]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male Wistar rats are subjected to partial hepatic ischemia [6] |
| Dosage: | 0.05 mg/kg |
| Administration: | I.p. injections at the start of reperfusion |
| Result: | Ameliorated reoxygenation injury and reproduced the hepatoprotective effects obtained by adenosine A2A receptor stimulation. |
| Animal Model: | Male C57BL/6 mice (8-12 weeks old; 20-30 g ) are subjected to renal ischemia [7] |
| Dosage: | 200 μg/kg |
| Administration: | I.p. injections 1 h before ischemia and then administers every 6 h after ischemia for 24 hr |
| Result: | Raised the level of serum creatinine and blood serum urea nitrogen. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
H 2 O : 50 mg/mL ( 143.99 mM ; ultrasonic and warming and heat to 60°C)
DMSO : 2.89 mg/mL ( 8.32 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.8799 mL | 14.3993 mL | 28.7985 mL |
| 5 mM | 0.5760 mL | 2.8799 mL | 5.7597 mL |
| 10 mM | 0.2880 mL | 1.4399 mL | 2.8799 mL |
References
- [1] Schmid AC, et, al. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett. 2004 May 21; 566(1-3): 35-8.
- [2] Kim MS, et, al. Nanotherapeutics of PTEN Inhibitor with Mesoporous Silica Nanocarrier Effective for Axonal Outgrowth of Adult Neurons. ACS Appl Mater Interfaces. 2016 Jul 27; 8(29): 18741-53.
- [3] Zhang B, et, al. Silencing of miR-19a-3p enhances osteosarcoma cells chemosensitivity by elevating the expression of tumor suppressor PTEN. Oncol Lett. 2019 Jan; 17(1): 414-421.
- [4] Dimchev GA, et, al. Phospho-tyrosine phosphatase inhibitor Bpv(Hopic) enhances C2C12 myoblast migration in vitro. Requirement of PI3K/AKT and MAPK/ERK pathways. J Muscle Res Cell Motil. 2013 May; 34(2): 125-36.
- [5] Raffel N, et, al. The effect of bpV(HOpic) on in vitro activation of primordial follicles in cultured swine ovarian cortical strips. Reprod Domest Anim. 2019 Aug; 54(8): 1057-1063.
- [6] Ponte CD, et, al. Pharmacological postconditioning protects against hepatic ischemia/reperfusion injury. Liver Transpl. 2011 Apr; 17(4): 474-82.
- [7] Zhou J,et, al. Pharmacological Inhibition of PTEN Aggravates Acute Kidney Injury. Sci Rep. 2017 Aug 25; 7(1): 9503.
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