[CAS NO. 72571-82-5] Pipemidic acid trihydrate
PRODUCTS SPECIFICATIONS [72571-82-5]
DESCRIPTION [72571-82-5]
Overview
| MDL | MFCD01690151 |
|---|---|
| Molecular Weight | 357.36 |
| Molecular Formula | C14H23N5O6 |
| SMILES | CCN1C=C(C(O)=O)C(C2=CN=C(N3CCNCC3)N=C21)=O.O.O.O |
Summary
Pipemidic acid trihydrate, a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid trihydrate inhibits DNA gyrase. Pipemidic acid trihydrate is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid trihydrate can be used for the research of intestinal, urinary, and biliary tract infections [1] [2] .
In Vitro
Pipemidic acid trihydrate is an inhibitor of DNA gyrase that is a bacterial enzyme which catalyzes the ATP-dependent negative supercoiling of DNA [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Pipemidic acid (50 mg/kg) trihydrate is absorbed well by the oral route, and the peak levels in plasma ranged from 4 to 12 μg/mL in mice, rats, dogs, monkeys
[3]
.
The mean lethal dose of Pipemidic acid trihydrate after a single oral dose was more than 16000 mg/kg in mice
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Iacovino R, et al. β-Cyclodextrin inclusion complex to improve physicochemical properties of pipemidic acid: characterization and bioactivity evaluation. Int J Mol Sci. 2013 Jun 25;14(7):13022-41.
- [2] Aoyama H, et, al. Purification of Citrobacter freundii DNA gyrase and inhibition by quinolones. Antimicrob Agents Chemother. 1988 Jan;32(1):104-9.
- [3] Shimizu M, et, al. Pipemidic acid: absorption, distribution, and excretion. Antimicrob Agents Chemother. 1975 Apr;7(4):441-6.
Synonyms