[CAS NO. 72822-13-0] Dapiprazolehydrochloride
PRODUCTS SPECIFICATIONS [72822-13-0]
DESCRIPTION [72822-13-0]
Overview
| MDL | MFCD00941400 |
|---|---|
| Molecular Weight | 361.91 |
| Molecular Formula | C19H28ClN5 |
| SMILES | CC1=CC=CC=C1N2CCN(CCC3=NN=C4CCCCN43)CC2.[H]Cl |
Summary
IC50 & Target
|
α1-adrenergic receptor |
In Vivo
Dapiprazole hydrochloride (0-10 mg/kg or 0-3 mg/mice; i.p. or i.c.v.; once) reduces the overall severity of the opiate withdrawal symptoms in mice [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Swiss Albino male CD-1 mice weighing 20 -25 g, acute dependence model (mice were injected i.p. with morphine (25 mg/kg) and 2 h later with naloxone (12.5 mg/kg)) [1] |
| Dosage: | 5, 7.5 and 10 mg/kg (i.p.) or 0.5, 1 and 3 mg/mice (i.c.v.), once |
| Administration: | Intraperitoneal injection or intracerebroventricular administration, once |
| Result: | Decreased jumping behavior, head shakes and paw shakes when administered just before naloxone. Resulted in a notable suppression of morphine withdrawal symptoms in a dose-related fashion when injected i.c.v.. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 50 mg/mL ( 138.16 mM ; Need ultrasonic)
DMSO : 12.5 mg/mL ( 34.54 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7631 mL | 13.8156 mL | 27.6312 mL |
| 5 mM | 0.5526 mL | 2.7631 mL | 5.5262 mL |
| 10 mM | 0.2763 mL | 1.3816 mL | 2.7631 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (138.16 mM); Clear solution; Need ultrasonic
References
- [1] Valeri P, et al. Effects of dapiprazole, clonidine and yohimbine on the development of dependence and withdrawal behaviour in mice. Drug Alcohol Depend. 1989 Jan;23(1):73-7.
- [2] Allinson RW, et al. Reversal of mydriasis by dapiprazole. Ann Ophthalmol. 1990 Apr;22(4):131-3, 138.
- [3] Hou RH, et al. Arousal and the pupil: why diazepam-induced sedation is not accompanied by miosis. Psychopharmacology (Berl). 2007 Nov;195(1):41-59.
Synonyms