[CAS NO. 729610-18-8] Calindol hydrochloride

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Catalog:	HY-122819
Brand:	MCE
CAS:	729610-18-8

Overview

MDL	-
Molecular Weight	336.86
Molecular Formula	C21H21ClN2
SMILES	C[C@@H](NCC1=CC2=CC=CC=C2N1)C3=C4C=CC=CC4=CC=C3.Cl

For research use only. We do not sell to patients.

Summary

Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC ₅₀ of 132 nM ^[1] .

In Vitro

In the presence of 2mM Ca ²⁺ , Calindol stimulates phosphatidylinositol (PI) accumulation with an EC ₅₀ of 1.0 μM or 0.31 μM in cells expressing the rat or the human CaSR, respectively ^[2] .
In wire myography studies, Calindol (1-10 µM) inhibits Methoxamine- and KCl-induced pre-contracted tone, and inhibits whole-cell voltage-gated Ca ²⁺ channel (VGCC) currents in rabbit mesenteric arteries ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Lionel Kiefer, et al. Design and synthesis of calindol derivatives as potent and selective calcium sensing receptor agonists. Bioorg Med Chem. 2016 Feb 15;24(4):554-69.
[2] Albane Kessler, et al. N2-benzyl-N1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1,2-diamines and conformationally restrained indole analogues: development of calindol as a new calcimimetic acting at the calcium sensing receptor. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3345-9.
[3] Harry Z E Greenberg, et al. The calcilytics Calhex-231 and NPS 2143 and the calcimimetic Calindol reduce vascular reactivity via inhibition of voltage-gated Ca2+ channels. Eur J Pharmacol. 2016 Nov 15;791:659-668.

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