[CAS NO. 730960-98-2]  NSC15520

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PRODUCTS SPECIFICATIONS [730960-98-2]

Catalog
HY-138155
Brand
MCE
CAS
730960-98-2

DESCRIPTION [730960-98-2]

Overview

MDL-
Molecular Weight418.52
Molecular FormulaC24H34O6
SMILESC[C@@]1(C(O)=O)CCC[C@]2(C)[C@]3([H])[C@]4(C(C(O)=O)[C@H]([C@@H](C3)C(C(C)C)=C4)C(O)=O)CC[C@@]12[H]

For research use only. We do not sell to patients.

Summary

NSC15520 is a small molecular inhibitor of Replication Protein A (RPA) . NSC15520 specifically recognizes the RPA N-terminal DNA binding domain (DBD), and blocks the interaction of RPA with p53 or RAD9. NSC15520 also inhibtis helix destabilization of a duplex DNA (dsDNA) oligonucleotide, involves in DNA replication, DNA repair, DNA recombination, and DNA damage response signaling [1] .


In Vitro

NSC15520 (10-.5-10-3.5 M) inhibits the interaction of RPA with GST-p53 peptide with an IC 50 value of 10 μM [1] .
NSC15520 (0-400 μM; 5 min) inhibits helix destabilization activity [1] .
NSC15520 (0-400 μM; 5 min) inhibits RPA binding of a dsDNA 30-mer [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


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Please store the product under the recommended conditions in the Certificate of Analysis.