MDL | - |
---|---|
Molecular Weight | 418.52 |
Molecular Formula | C24H34O6 |
SMILES | C[C@@]1(C(O)=O)CCC[C@]2(C)[C@]3([H])[C@]4(C(C(O)=O)[C@H]([C@@H](C3)C(C(C)C)=C4)C(O)=O)CC[C@@]12[H] |
NSC15520 is a small molecular inhibitor of Replication Protein A (RPA) . NSC15520 specifically recognizes the RPA N-terminal DNA binding domain (DBD), and blocks the interaction of RPA with p53 or RAD9. NSC15520 also inhibtis helix destabilization of a duplex DNA (dsDNA) oligonucleotide, involves in DNA replication, DNA repair, DNA recombination, and DNA damage response signaling [1] .
NSC15520 (10-.5-10-3.5 M) inhibits the interaction of RPA with GST-p53 peptide with an IC
50
value of 10 μM
[1]
.
NSC15520 (0-400 μM; 5 min) inhibits helix destabilization activity
[1]
.
NSC15520 (0-400 μM; 5 min) inhibits RPA binding of a dsDNA 30-mer
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Room temperature in continental US; may vary elsewhere.
Please store the product under the recommended conditions in the Certificate of Analysis.