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[CAS NO. 7336-33-6] 3-Demethylcolchicine

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Catalog:	HY-W021267
Brand:	MCE
CAS:	7336-33-6

Overview

MDL	-
Molecular Weight	385.41
Molecular Formula	C21H23NO6
SMILES	CC(N[C@H](C1=C2)CCC3=CC(O)=C(OC)C(OC)=C3C1=CC=C(OC)C2=O)=O

For research use only. We do not sell to patients.

Summary

3-Demethylcolchicine, a colchicine metabolite, possesses a hydroxy-group on its carbon ring that could participate in radical scavenging and markedly inhibits the carrageenin edema ^[1] ^[2] .

Appearance

Solid

Source

Plants
other families

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 259.46 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5946 mL	12.9732 mL	25.9464 mL
5 mM	0.5189 mL	2.5946 mL	5.1893 mL
10 mM	0.2595 mL	1.2973 mL	2.5946 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.49 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.49 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.49 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Modriansky M, et al. Anti-/pro-oxidant effects of phenolic compounds in cells: are colchicine metabolites chain-breaking antioxidants?. Toxicology. 2002;177(1):105-117.
[2] Sugio K, et al. Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congeners. Life Sci. 1987;40(1):35-39.

Synonyms

Acetamide, N-[(7S)-5,6,7,9-tetrahydro-3-hydroxy-1,2,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-

Colchicine, O³-demethyl-

Acetamide, N-(5,6,7,9-tetrahydro-3-hydroxy-1,2,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-

Colchicine, 2-demethyl-

Benzo[a]heptalene, acetamide deriv.

N-[(7S)-5,6,7,9-Tetrahydro-3-hydroxy-1,2,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide

3-Demethylcolchicine

3-Desmethylcolchicine

O³-Demethylcolchicine

3-Demethyl-(-)-colchicine

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