[CAS NO. 73604-30-5] (-)-Bicuculline methobromide
PRODUCTS SPECIFICATIONS [73604-30-5]
DESCRIPTION [73604-30-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 462.29 |
| Molecular Formula | C21H20BrNO6 |
| SMILES | C[N+]1(C)[C@@H]([C@H]2OC(C3=C4OCOC4=CC=C32)=O)C5=C(C=C6C(OCO6)=C5)CC1.[Br-] |
Summary
(-)-Bicuculline methobromide (l-Bicuculline methobromide) is a potent GABA A receptor antagonist. (-)-Bicuculline methobromide blocks afterhyperpolarizations (AHPs) mediated by Ca 2+ -activated K + channels in various types of neurons [1] .
IC50 & Target
GABA A [1]
In Vivo
(-)-Bicuculline methobromide (0.6 nmol/rat) attenuates the antiallodynic effect of Neurotropin
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Rat L5-SNL model [2] |
| Dosage: | 0.6 nmol/rat |
| Administration: | Intrathecal injection, 5 minutes before administration of Neurotropin (100 NU/kg, i.v.) |
| Result: | Attenuated the antiallodynic effect of Neurotropin. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL ( 108.16 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1631 mL | 10.8157 mL | 21.6314 mL |
| 5 mM | 0.4326 mL | 2.1631 mL | 4.3263 mL |
| 10 mM | 0.2163 mL | 1.0816 mL | 2.1631 mL |
References
- [1] Seutin V, et al. Recent advances in the pharmacology of quaternary salts of bicuculline. Trends Pharmacol Sci. 1999 Jul;20(7):268-70.
- [2] Okazaki R, et al. The antiallodynic effect of Neurotropin is mediated via activation of descending pain inhibitory systems in rats with spinal nerve ligation. Anesth Analg. 2008 Sep;107(3):1064-9.