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[CAS NO. 738-87-4] Sterculicacid
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-127143 |
| Brand: | MCE |
| CAS: | 738-87-4 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 294.47 |
| Molecular Formula | C19H34O2 |
| SMILES | CCCCCCCCC1=C(C1)CCCCCCCC(O)=O |
Summary
Sterculic acid is a stearoyl-CoA desaturase-1 ( SCD1 ) inhibitor. Sterculic acid specifically inhibits the delta-9 desaturase ( Δ9D ) activity with an IC 50 value of 0.9 μM [1] .
IC50 & Target
|
delta-9 desaturase 0.9 μM (IC 50 ) |
In Vitro
Sterculic acid (SA) is a cyclopropene fatty acid originally found in the seeds of the plant
Sterculia foetida
with numerous biological activities
Sterculic acid is able to reduce adrenomedullin expression (AP, RP, APS, IML, in preparation)
Sterculic acid is also able to mediate anti-inflammatory and protective effects
Sterculic acid has a potent luteolytic effect in ovines by inhibition in the synthesis of progesterone, which causes luteal regression
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Sterculic acid has been proposed as a potential tool for the treatment of metabolic syndrome (MS) since it inhibits the activity of the stearoyl-CoA desaturase-1 (SCD1)
in vivo
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Liquid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
References
- [1] Lei Zhang, et al. A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors. J Biomol Screen. 2010 Feb;15(2):169-76.
- [2] Rafael Peláez, et al. Sterculic Acid: The Mechanisms of Action beyond Stearoyl-CoA Desaturase Inhibition and Therapeutic Opportunities in Human Diseases. Cells. 2020 Jan 7;9(1):140.
- [3] Abril Ramírez-Higuera, et al. Preventive Action of Sterculic Oil on Metabolic Syndrome Development on a Fructose-Induced Rat Model. J Med Food. 2020 Mar;23(3):305-311.
Synonyms
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