[CAS NO. 73963-62-9] 3,4-DehydroCilostazol
PRODUCTS SPECIFICATIONS [73963-62-9]
DESCRIPTION [73963-62-9]
Overview
| MDL | MFCD08063649 |
|---|---|
| Molecular Weight | 367.44 |
| Molecular Formula | C20H25N5O2 |
| SMILES | O=C1NC2=C(C=C(OCCCCC3=NN=NN3C4CCCCC4)C=C2)C=C1 |
Summary
3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol (CLZ; HY-17464). 3,4-Dehydro Cilostazol is used for pharmacokinetic study [1] .
In Vivo
3,4-Dehydro Cilostazol (OPC-13015; Oral; 1 mg/kg GLZ and 10 mg/kg CLZ) has a T
1/2
of 3.94 hours, a C
max
of 1.39 μM and an AUC
0-24
of 4.69 μg•h/ml. The plasma concentration time profiles of GLZ, CLZ & its active metabolite DCLZ are traceable up to 24 h, 12 h and 12 h respectively by oral administration at 1 mg/kg dose of GLZ and 10 mg/kg CLZ
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male Wistar rats weighing 200 g [1] |
| Dosage: | 1 mg/kg Glipizide (GLZ) and 10 mg/kg Cilostazol (CLZ) (Pharmacokinetic Analysis) |
| Administration: | Oral |
| Result: | Had a T 1/2 of 3.94 hours, a C max of 1.39 μM and an AUC 0-24 of 4.69 μg•h/ml. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 5 mg/mL ( 13.61 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7215 mL | 13.6077 mL | 27.2153 mL |
| 5 mM | 0.5443 mL | 2.7215 mL | 5.4431 mL |
| 10 mM | 0.2722 mL | 1.3608 mL | 2.7215 mL |