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[CAS NO. 7415-78-3] β-Hydroxyisovalerylshikonin
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-N4201 |
| Brand: | MCE |
| CAS: | 7415-78-3 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 388.41 |
| Molecular Formula | C21H24O7 |
| SMILES | CC(C)(O)CC(O[C@@H](C(C1=O)=CC(C2=C1C(O)=CC=C2O)=O)C/C=C(C)\C)=O |
Summary
Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon , acts as a potent inhibitor of protein tyrosine kinases (PTK) , with IC 50 s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells [1] .
IC50 & Target
IC50: 0.7 μM (EGFR), 1 μM (v-Src) [1]
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 10 mg/mL ( 25.75 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5746 mL | 12.8730 mL | 25.7460 mL |
| 5 mM | 0.5149 mL | 2.5746 mL | 5.1492 mL |
| 10 mM | 0.2575 mL | 1.2873 mL | 2.5746 mL |
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1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 1 mg/mL (2.57 mM); Clear solution
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