[CAS NO. 74392-49-7] PPACK II
PRODUCTS SPECIFICATIONS [74392-49-7]
DESCRIPTION [74392-49-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 501.02 |
| Molecular Formula | C25H33ClN6O3 |
| SMILES | N=C(N)NCCC[C@@H](C(CCl)=O)NC([C@@H](NC([C@H](N)CC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O |
Summary
PPACK II is an irreversible and specific glandular and plasma kallikreins inhibitor [1] .
In Vitro
PPACK II (0.62-50 μg/mL) significantly inhibits B-type natriuretic peptide (BNP) proteolysis [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Kentaro Takayama, et al. Identification of a degrading enzyme in human serum that hydrolyzes a C-terminal core sequence of neuromedin U. Biopolymers. 2016 Nov 4;106(4):440-5.
- [2] Alexander Belenky, et al. The effect of class-specific protease inhibitors on the stabilization of B-type natriuretic peptide in human plasma. Clin Chim Acta. 2004 Feb;340(1-2):163-72.