[CAS NO. 745046-84-8] Ivachtin
PRODUCTS SPECIFICATIONS [745046-84-8]
DESCRIPTION [745046-84-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 447.46 |
| Molecular Formula | C20H21N3O7S |
| SMILES | O=C1N(CCOC(C)=O)C(C2=C1C3=CC(S(=O)(N4CCOCC4)=O)=CC=C3N=C2C)=O |
Summary
Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC 50 of 23 nM. Ivachtin has modest selectivity for the remaining caspases [1] .
IC50 & Target
|
Caspase-3 23 nM (IC 50 ) |
In Vitro
Ivachtin (Caspase-3 Inhibitor VII; compound 7a; 10, 100 μM) has protective effect in a model of staurosporininduced apoptosis in human Jurkat T cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)