[CAS NO. 745055-91-8] UBP 302
PRODUCTS SPECIFICATIONS [745055-91-8]
DESCRIPTION [745055-91-8]
Overview
| MDL | MFCD06411607 |
|---|---|
| Molecular Weight | 333.30 |
| Molecular Formula | C15H15N3O6 |
| SMILES | O=C(N(C=CC1=O)C[C@H](N)C(O)=O)N1CC2=C(C=CC=C2)C(O)=O |
Summary
UBP 302 is a potent and selective GLUK5-subunit containing kainate receptor antagonist (apparent K d =402 nM), and displays very little affinity on GluK2 (GluR6) kainate receptors. Anxiolytic effects [1] [2] [3] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
References
- [1] More JC, et al. Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology. 2004 Jul;47(1):46-64.
- [2] Dolman NP, et al. Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J Med Chem. 2005 Dec 1;48(24):7867-81.
- [3] Apland JP, et al. The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302. J Pharmacol Exp Ther. 2014 Nov;351(2):359-72.
Synonyms