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[CAS NO. 756875-51-1] K6PC-5
| Ships within | Stock | Price | Qty | Total |
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| Catalog: | HY-124042 |
| Brand: | MCE |
| CAS: | 756875-51-1 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 343.50 |
| Molecular Formula | C19H37NO4 |
| SMILES | CCCCCCCC(C(C(NC(CO)CO)=O)CCCCCC)=O |
Summary
IC50 & Target
|
SphK1
|
In Vitro
K6PC-5 (1-10 μM; 24 h) increases the involucrin and loricrin levels in a dose-dependent manner in normal human epidermal keratinocytes (NHEKs). K6PC-5 promotes differentiation and proliferation of keratinocytes via intracellular Ca
2+
signaling. In addition, K6PC-5 stimulates the phosphorylation of p42/44 extracellular signal-regulated kinase and c-Jun N-terminal kinase
[1]
.
K6PC-5 (1-10 μM; 24 h) promotes fibroblasts proliferation and collagen synthesis in human fibroblasts. K6PC-5 induces intracellular Ca
2+
concentration ([Ca
2+
]
i
) oscillations in human fibroblasts
[2]
.
K6PC-5 (10, 25, and 50 μM; 48 h) significantly attenuates EBOV-induced infection in EBOV-infected EA.hy926 cells. K6PC-5 significantly reduces the virus titers in supernatants of infected cells and strikingly decreased the amount of VP40 in a concentration-dependent manner
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [1]
| Cell Line: | Normal human epidermal keratinocytes (NHEKs) |
| Concentration: | 1 μM, 5 μM, 10 μM |
| Incubation Time: | 24 h |
| Result: | Increased the involucrin and loricrin levels in a dose-dependent manner. |
Cell Proliferation Assay [2]
| Cell Line: | Human fibroblasts |
| Concentration: | 1 μM, 5 μM, 10 μM |
| Incubation Time: | 24 h |
| Result: | Promoted fibroblast proliferation and procollagen production in human fibroblasts significantly. |
In Vivo
In intrinsically aged hairless mice (56 weeks old), 1% K6PC-5 is applied topically for 2 weeks. This K6PC-5 treatment significantly increases both the number of dermal fibroblasts and collagen production. As a consequence, dermal thickness also increased significantly [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Intrinsically aged hairless mice (56 weeks old) [2] |
| Dosage: | 1% (vehicle (PEG:EtOH = 7:3)) |
| Administration: | Topical application; twice daily for 2 weeks |
| Result: | Enhanced fibroblast proliferation, collagen production, and eventually increased dermal thickness. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 291.12 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9112 mL | 14.5560 mL | 29.1121 mL |
| 5 mM | 0.5822 mL | 2.9112 mL | 5.8224 mL |
| 10 mM | 0.2911 mL | 1.4556 mL | 2.9112 mL |
References
- [1] Kwon YB, et al. Novel synthetic ceramide derivatives increase intracellular calcium levels and promote epidermal keratinocyte differentiation. J Lipid Res. 2007 Sep;48(9):1936-43.
- [2] Jong-Kyung Youm, et al. K6PC-5, a sphingosine kinase activator, induces anti-aging effects in intrinsically aged skin through intracellular Ca2+ signaling. J Dermatol Sci. 2008 Aug;51(2):89-102.
- [3] Imre G, et al. The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection. iScience. 2021 Mar 5;24(4):102266.
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