[CAS NO. 76343-94-7] Latrunculin B

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PRODUCTS SPECIFICATIONS [76343-94-7]

Catalog

HY-101848

Brand

MCE

CAS

76343-94-7

DESCRIPTION [76343-94-7]

Overview

MDL	-
Molecular Weight	395.51
Molecular Formula	C20H29NO5S
SMILES	O=C1SC[C@@H]([C@]2(O)O[C@]3([H])CC[C@H](C)/C=C\CC/C(C)=C\C(O[C@@](C3)([H])C2)=O)N1

For research use only. We do not sell to patients.

Summary

Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity ^[1] ^[2] .

In Vitro

Latrunculin B displays growth inhibition of HeLa cells with an IC ₅₀ value of 1.4 μM ^[1] .
Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes. Latrunculin B (100 nM) decreases the spontaneous electrical activity by 16±4% in pulmonary vein (PV) preparations. Latrunculin B (100 nM) decreases the late Na ⁺ current, L-type Ca ²⁺ current, Na ⁺ /Ca ²⁺ exchanger current, and stretch-activated BKCa current in PV cardiomyocytes. Latrunculin B reduces the transient outward K ⁺ current and ultra-rapid delayed rectifier K ⁺ current, but increases the delayed rectifier K ⁺ current in isolated PV cardiomyocytes. Latrunculin B (100 nM) decreases intracellular Ca ²⁺ transient and sarcoplasmic reticulum Ca ²⁺ content in PV cardiomyocytes. Latrunculin B attenuates stretch-induced increased spontaneous electrical activity and trigger activity ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT03678597	Ibn Sina Hospital	Infertility	September 25, 2018	Not Applicable

Appearance

Oil

Source

Red Sea sponge

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

References

Synonyms

2-Thiazolidinone, 4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-, (4R)-

2-Thiazolidinone, 4-(15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl)-, [1R-[1R*,4Z,8Z,10S*,13R*,15R*(R*)]]-

2,13-Dioxabicyclo[11.3.1]heptadecane, 2-thiazolidinone deriv.

(4R)-4-[(1R,4Z,8Z,10S,13R,15R)-15-Hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone

Latrunculin B

NSC 339663