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[CAS NO. 76896-80-5] Triacsin C
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-N6707 |
| Brand: | MCE |
| CAS: | 76896-80-5 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 207.27 |
| Molecular Formula | C11H17N3O |
| SMILES | CCC/C=C/C/C=C/C=C/C=N/NN=O |
Summary
Triacsin C (WS 1228A), a natural intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, is from Streptomyces aureofaciens . Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity [1] . Triacsin C is found to be highly effective against rotavirus replication [2] .
IC50 & Target
IC50: 3.70 μM (CpACS1), 2.32 μM (CpACS2) [3]
In Vitro
Triacsin C (0-16 μM; 41 h) inhibits parasite fatty acyl-coenzyme A synthetases, and reduces CpACS1 and CpACS2 enzymes activities with IC
50
s of 3.70 μM and 2.32 μM, respectively, with K
i
values of 595 nM and 106 nM, respectively
[3]
.
Triacsin C (0-16 μM; 41 h) shows anti-parasitic and inhibits
Cryptosporidium parvum
with an IC
50
value of 136 nM
[3]
.
Triacsin C (0, 0.25, 0.5 μM; 30 min) has no effect on parasite invasion
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Triacsin C (8-15 mg/kg/d; p.o.; 1 week) shows anticryptosporidial efficacy and improves
Cryptosporidium parvum
infection by targeting parasite fatty acyl-coenzyme A synthetases
[3]
.
Triacsin C (10 mg/kg/d; p.o.; 2 months) exhibits anti-atherosclerotic activity in aortic atherosclerosis LDLR
-/-
mice
[4]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Cryptosporidium -infected interleukin knockout mice [3] |
| Dosage: | 8-15 mg/kg/d |
| Administration: | Oral gavage; 1 week |
| Result: | Reduced parasite oocyst production up to 88.1% with no apparent toxicity. |
| Animal Model: | Low-density lipoprotein receptor-knockout (LDLR -/- ) mice (C57BL/6 background) [4] |
| Dosage: | 10 mg/kg/d |
| Administration: | Oral gavage; 2 months |
| Result: |
Increased plasma TG, plasma cholesterol, plasma free fatty acid, and plasma glucose concentration.
Improved the growth of aortic atherosclerosis mice, increased the body weight of mince. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 5 mg/mL ( 24.12 mM ; Need ultrasonic and warming)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.8246 mL | 24.1231 mL | 48.2462 mL |
| 5 mM | 0.9649 mL | 4.8246 mL | 9.6493 mL |
| 10 mM | 0.4825 mL | 2.4123 mL | 4.8246 mL |
References
- [1] Dechandt CRP, et al. Triacsin C reduces lipid droplet formation and induces mitochondrial biogenesis in primary rat hepatocytes. J Bioenerg Biomembr. 2017 Oct;49(5):399-411.
- [2] Kim Y, et al. Novel triacsin C analogs as potential antivirals against rotavirus infections. Eur J Med Chem. 2012 Apr;50:311-8.
- [3] Guo F, et al. Amelioration of Cryptosporidium parvum infection in vitro and in vivo by targeting parasite fatty acyl-coenzyme A synthetases. J Infect Dis. 2014 Apr 15;209(8):1279-87.
- [4] Matsuda D, et al. Anti-atherosclerotic activity of triacsin C, an acyl-CoA synthetase inhibitor. J Antibiot (Tokyo). 2008 May;61(5):318-21.
Synonyms
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