[CAS NO. 7694-45-3] Perillic acid
PRODUCTS SPECIFICATIONS [7694-45-3]
DESCRIPTION [7694-45-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 166.22 |
| Molecular Formula | C10H14O2 |
| SMILES | O=C(C1=CCC(C(C)=C)CC1)O |
Summary
IC50 & Target
|
HSV-1 |
In Vitro
Perillic acid (1-5 mM; 24 h) decreases A549 cells survival in a dose-dependent manner
[1]
.
Perillic acid (1 mM; 24 h) induces S-phase arrest in A549 cells and induces G2/M arrest in H520 cells
[1]
.
Perillic acid (2 mM; 24 h) induces A549 and H520 cells apoptosis
[1]
.
Perillic acid (0-50 μM; 24 h) shows potential antiviral activity primarily against the 17
syn
+ HSV-1 strain (EC
50
KOS: 2.84 μM; 17
syn
+: 1.08 μM)
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Cytotoxicity Assay [1]
| Cell Line: | A549 cells |
| Concentration: | 1, 2, 3, 4 and 5 mM |
| Incubation Time: | 24 h |
| Result: | Resulted in decreased survival in a dose-dependent manner with an IC 50 of 3.6 mM. |
Cell Cycle Analysis [1]
| Cell Line: | A549 and H520 cells |
| Concentration: | 1 mM |
| Incubation Time: | 24 h |
| Result: | Induced S-phase arrest in A549 cells and induced G2/M arrest in H520 cells. |
Apoptosis Analysis [1]
| Cell Line: | A549 and H520 cells |
| Concentration: | 2 mM |
| Incubation Time: | 24 h |
| Result: | Increased apoptosis to 27% in A549 and to 18% in H520 cells compared to control (12%). |
Western Blot Analysis [1]
| Cell Line: | H520 cells |
| Concentration: | 0.5 mM |
| Incubation Time: | 24 h |
| Result: | Increased Bax expression and decreased procaspase-3 levels. |
In Vivo
Perillic acid (50 μM/kg; i.p.; daily for 5 days) shows immunomodulatory activity in mice [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Balb/c mice [3] |
| Dosage: | 50 μM/kg |
| Administration: | Intraperitoneal injection, daily for 5 days |
| Result: | Increased the total white blood cells (WBC) count. Increased the total antibody production, antibody producing cells in spleen, bone marrow cellularity and α-esterase positive cells significantly compared to the normal animals. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Yeruva L, et al. Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells. Cancer Lett. 2007 Nov 18;257(2):216-26.
- [2] Mello CP, et al. Perillyl alcohol and perillic acid exert efficient action upon HSV-1 maturation and release of infective virus. Antivir Ther. 2020;25(1):1-11.
- [3] Raphael TJ, et al. Immunomodulatory activity of naturally occurring monoterpenes carvone, limonene, and perillic acid. Immunopharmacol Immunotoxicol. 2003 May;25(2):285-94.