[CAS NO. 77-48-5] 1,3-Dibromo-5,5-dimethylhydantoin

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PRODUCTS SPECIFICATIONS [77-48-5]

Catalog

HY-Y0786

Brand

MCE

CAS

77-48-5

DESCRIPTION [77-48-5]

Overview

MDL	MFCD00003189
Molecular Weight	285.92
Molecular Formula	C5H6Br2N2O2
SMILES	O=C1N(Br)C(C(C)(C)N1Br)=O

For research use only. We do not sell to patients.

Summary

1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs ^[1] .

IC50 & Target

Alkyl-Chain

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Synonyms

2,4-Imidazolidinedione, 1,3-dibromo-5,5-dimethyl-

Hydantoin, 1,3-dibromo-5,5-dimethyl-

1,3-Dibromo-5,5-dimethyl-2,4-imidazolidinedione

1,3-Dibromo-5,5-dimethylhydantoin

N,N′-Dibromodimethylhydantoin

Dibromantin

Dibromantine

5,5-Dimethyl-1,3-dibromohydantoin

N,N′-Dibromo-5,5-dimethylhydantoin

NSC 33305

1,3-Dibromo-5,5-dimethylimidazolidine-2,4-dione

1,3-Dibromo-5,5-dimethylimidazolidin-2,4-dione

Dibromohydantoin