[CAS NO. 7720-39-0] 2-Aminoimidazole
PRODUCTS SPECIFICATIONS [7720-39-0]
DESCRIPTION [7720-39-0]
Overview
| MDL | MFCD00792530 |
|---|---|
| Molecular Weight | 83.09 |
| Molecular Formula | C3H5N3 |
| SMILES | NC1=NC=CN1 |
Summary
2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of human arginase I with a K i of 3.6 mM [1] [2] [3] .
Appearance
Liquid
Source
secondary metabolites in various marine sponges
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL ( 601.76 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 12.0351 mL | 60.1757 mL | 120.3514 mL |
| 5 mM | 2.4070 mL | 12.0351 mL | 24.0703 mL |
| 10 mM | 1.2035 mL | 6.0176 mL | 12.0351 mL |
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Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (30.09 mM); Clear solution
References
- [1] Thompson RJ, et, al. Identification of BfmR, a response regulator involved in biofilm development, as a target for a 2-Aminoimidazole-based antibiofilm agent. Biochemistry. 2012 Dec 11;51(49):9776-8.
- [2] Jacobs L, et, al. 2-Aminoimidazoles as potent inhibitors of contaminating brewery biofilms. Biofouling. 2021 Feb 11;1-17.
- [3] Ilies M, et, al. 2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I. J Med Chem. 2010 May 27;53(10):4266-76.
Synonyms