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[CAS NO. 78842-13-4] 2′-Deoxy-2′-fluoroguanosine
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-W011518 |
| Brand: | MCE |
| CAS: | 78842-13-4 |
Overview
| MDL | MFCD00923832 |
|---|---|
| Molecular Weight | 285.23 |
| Molecular Formula | C10H12FN5O4 |
| SMILES | OC[C@@H]1[C@@H](O)[C@@H](F)[C@H](N2C(NC(N)=NC3=O)=C3N=C2)O1 |
Summary
2′-Deoxy-2′-fluoroguanosine, a nucleoside analog, is a potent inhibitor of influenza virus strains, with an EC 90 of <0.35 μM for influenza virus A and B strains. 2′-Deoxy-2′-fluoroguanosine significantly inhibits replication of influenza virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation [1] [2] .
IC50 & Target
EC90: <0.35 μM (influenza virus A and B) [1]
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL ( 175.30 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.5059 mL | 17.5297 mL | 35.0594 mL |
| 5 mM | 0.7012 mL | 3.5059 mL | 7.0119 mL |
| 10 mM | 0.3506 mL | 1.7530 mL | 3.5059 mL |
References
- [1] Tisdale M, et, al. Inhibition of influenza virus transcription by 2'-deoxy-2'-fluoroguanosine. Antimicrob Agents Chemother. 1995 Nov;39(11):2454-8.
- [2] Jakeman KJ, et, al. Efficacy of 2'-deoxy-2'-fluororibosides against influenza A and B viruses in ferrets. Antimicrob Agents Chemother. 1994 Aug;38(8):1864-7.
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