MDL | - |
---|---|
Molecular Weight | 312.45 |
Molecular Formula | C21H28O2 |
SMILES | O=C1CC[C@]2([H])[C@@]3([H])CC[C@]4(CC)[C@@](C#C)(O)CC[C@@]4([H])[C@]3([H])CCC2=C1 |
Levonorgestrel is a synthetic progestogen used as an active ingredient in some hormonal contraceptives. Target: Progesterone Receptor A synthetic progestational hormone with actions similar to those of progesterone and about twice as potent as its racemic or (+-)-isomer (norgestrel). It is used for contraception, control of menstrual disorders, and treatment of endometriosis. It is usually supplied in a racemic mixture (Norgestrel, 6533-00-2). Only the levonorgestrel isomer is active. Levonorgestrel is marketed mostly as a combination oral contraceptive under several brand names such as Alesse, Triphasil, and Min-Ovral [1].
NCT Number | Sponsor | Condition | Start Date | Phase |
---|---|---|---|---|
NCT04972396 | Altimmune, Inc. |
NASH - Nonalcoholic Steatohepatitis
|
October 5, 2021 | Phase 1 |
NCT02357368 | Lisa Haddad|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Emory University |
HIV|Contraception
|
February 2015 | Phase 4 |
NCT00360490 | Bayer |
Menorrhagia
|
July 2006 | Phase 3 |
NCT01833793 | Bayer |
Female Contraception
|
February 2013 | |
NCT04142762 | Assembly Biosciences |
Chronic Hepatitis B
|
October 18, 2019 | Phase 1 |
NCT00551616 | HRA Pharma |
Contraception
|
April 2007 | Phase 3 |
NCT01623466 | Agile Therapeutics |
Healthy
|
July 2012 | Phase 1|Phase 2 |
NCT01414140 | Bayer |
Contraception
|
May 2007 | |
NCT01320917 | University of Sao Paulo |
Contraception Desired|Obesity
|
February 2009 | Phase 4 |
NCT01873170 | University of Pittsburgh |
HIV|Immune Cells (Mucosal and Systemic)|Contraception
|
August 2013 | |
NCT02531321 | University of Southern California |
Contraception|HIV
|
August 2015 | Phase 4 |
NCT01508858 | Novo Nordisk A+S |
Diabetes|Diabetes Mellitus, Type 2
|
November 2006 | Phase 1 |
NCT02173808 | Health Decisions|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
Contraceptive Usage
|
May 2011 | Phase 1 |
NCT01096485 | Bayer |
Contraception|Contraception, Postcoital
|
February 2009 | Phase 1 |
NCT01240811 | Sharon Achilles|University of Pittsburgh |
Genital Tract Mucosal Immunity|Genital Tract Microflora
|
November 2010 | Not Applicable |
NCT02159131 | ViiV Healthcare |
Infections, Human Immunodeficiency Virus and Hepatitis
|
August 2014 | Phase 1 |
NCT01230242 | Rebecca Hunt|MaineHealth |
Estimating Rates of Expulsion
|
September 7, 2010 | Not Applicable |
NCT00781456 | Duramed Research|Teva Branded Pharmaceutical Products R&D, Inc. |
Migraine
|
January 2009 | Phase 2 |
NCT00204451 | University of Saskatchewan|Canadian Institutes of Health Research (CIHR) |
Contraception
|
July 2005 | Phase 4 |
NCT01963962 | University of Utah |
Emergency Contraception
|
July 2013 | |
NCT00868153 | Bayer |
Idiopathic Menorrhagia
|
August 2004 | |
NCT01595022 | Bayer |
Contraception
|
January 2010 | Phase 1 |
NCT04897217 | Wake Forest University Health Sciences|National Cancer Institute (NCI) |
Endometrial Hyperplasia
|
January 2023 | Phase 3 |
NCT01297348 | Pfizer|Boston Collaborative Drug Surveillance Program |
Venous Thrombosis|Pulmonary Embolism|Sinus Thrombosis, Intracranial
|
July 2007 | |
NCT00924560 | Duramed Research|Teva Branded Pharmaceutical Products R&D, Inc. |
Bone Mineral Density
|
June 2009 | Phase 2 |
NCT05444582 | University of Utah|Planned Parenthood Federation of America |
Contraception
|
November 15, 2022 | |
NCT02002260 | Women and Infants Hospital of Rhode Island |
Abnormal Uterine Bleeding|Abnormal Uterine Bleeding, Ovulatory Dysfunction|Abnormal Uterine Bleeding, Endometrial Hemostatic Dysfunction
|
February 2013 | Not Applicable |
NCT00864136 | Bayer |
Menorrhagia
|
November 2008 | |
NCT01085487 | Bayer |
Idiopathic Menorrhagia
|
April 2009 | |
NCT03353012 | Chulalongkorn University |
Breastfeeding|Post Partum
|
January 1, 2018 | Phase 4 |
NCT03819114 | AIDS Clinical Trials Group|National Institute of Allergy and Infectious Diseases (NIAID) |
HIV Infections|Tuberculosis
|
May 6, 2019 | Phase 2 |
NCT02021097 | Regenex Pharmaceutical, China |
Oral Contraceptive
|
February 2012 | Phase 3 |
NCT03455075 | Health Decisions|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center|University of Washington |
Healthy|Men|Male Contraception
|
April 16, 2018 | Phase 2 |
NCT00922233 | FHI 360 |
Healthy
|
January 2010 | Phase 3 |
NCT02957292 | Fundació Institut de Recerca de l´Hospital de la Santa Creu i Sant Pau|Bayer |
Contraception
|
June 1, 2016 | Phase 4 |
NCT00445887 | Gynecologic Oncology Group|National Cancer Institute (NCI)|GOG Foundation |
Ovarian Carcinoma
|
March 10, 2008 | Phase 2 |
NCT04785950 | Bayer |
Hormonal Intrauterine Contraception
|
February 25, 2021 | |
NCT00621543 | Boston University|University of Utah |
Intrauterine Device Expulsion|Medical Abortion|Induced Abortion
|
March 2006 | Not Applicable |
NCT01539720 | Planned Parenthood of the St. Louis Region and Southwest Missouri|William and Flora Hewlett Foundation|University of Colorado, Denver|Planned Parenthood Federation of America|University of Rochester |
Pregnancy, Unplanned|Pregnancy; Accident
|
December 2012 | Not Applicable |
NCT01789879 | University of Nebraska|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Makerere University|University of Liverpool |
HIV|Contraception
|
June 2013 | Phase 2 |
NCT01328184 | Boehringer Ingelheim |
Healthy
|
April 2011 | Phase 1 |
NCT02104609 | University of Southern California|Society of Family Planning |
Obesity
|
April 2013 | |
NCT00271583 | University of Pittsburgh|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
Emergency Contraception
|
September 1999 | Phase 2|Phase 3 |
NCT01291004 | Teva Branded Pharmaceutical Products R&D, Inc. |
Follicle Development|Ovarian Follicle|Follicle Count|Follicle Size|Oral Contraceptive
|
January 31, 2011 | Phase 1 |
NCT00455845 | Mahidol University |
Endometriosis|Pelvic Pain|Dysmenorrhea
|
April 2007 | Phase 3 |
NCT03359057 | Galeno Desenvolvimento de Pesquisas Clínicas|Biolab Sanus Farmaceutica |
Contraception
|
February 26, 2013 | Phase 3 |
NCT01731132 | Bayer |
Contraception
|
July 2012 | |
NCT00931827 | Bayer |
Contraception
|
January 2008 | |
NCT00131885 | University of Utah|National Center for Complementary and Integrative Health (NCCIH) |
Contraception
|
August 2005 | Phase 4 |
NCT04676776 | Gynuity Health Projects|Cuidado Integral de la Mujer, Gineclinic, S.C. |
Missed Menstrual Period
|
January 25, 2021 | Phase 2 |
NCT01250210 | Agile Therapeutics |
Ovulation Suppression
|
September 2007 | Phase 2 |
NCT02475356 | Bayer |
Menorrhagia, Dysmenorrhea
|
August 4, 2015 | |
NCT03537768 | Health Decisions|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
Contraception
|
July 12, 2018 | Phase 4 |
NCT01590537 | Bayer |
Contraception
|
September 2011 | |
NCT01686126 | Queensland Centre for Gynaecological Cancer|The University of Queensland|Queensland University of Technology |
Complex Endometrial Hyperplasia With Atypia|Grade 1 Endometrial Endometrioid Adenocarcinoma
|
December 2012 | Phase 2 |
NCT00669396 | University of Utah |
Pregnancy
|
April 2008 | Not Applicable |
NCT02574715 | Bayer |
Quality of Life
|
September 18, 2015 | |
NCT05044962 | University of Washington|Moi Teaching and Referral Hospital|Indiana University|University of Nebraska|National Institute of Allergy and Infectious Diseases (NIAID) |
HIV Infections|Contraception|Drug-drug Interaction
|
November 26, 2021 | Not Applicable |
NCT01721798 | FHI 360|University of Cape Town|City University of New York, School of Public Health |
HIV
|
November 10, 2013 | Not Applicable |
NCT01252186 | Teva Women´s Health|Teva Branded Pharmaceutical Products R&D, Inc. |
Hemostasis|Oral Contraceptive
|
November 2010 | Phase 2 |
NCT01166412 | Health Decisions|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
Contraception
|
December 2010 | Phase 1|Phase 2 |
NCT00520455 | University of Washington|Centers for Disease Control and Prevention |
Pregnancy
|
January 2004 | Not Applicable |
NCT02362373 | Columbia University|Bayer |
Epilepsy|Contraception
|
August 2011 | Phase 4 |
NCT00570440 | FHI 360|La Asociación Pro Bienestar de la Familia de Guatemala (APROFAM) |
Pregnancy Prevention
|
August 2007 | Phase 4 |
NCT01044056 | Organon and Co |
Contraception
|
March 2004 | Phase 4 |
NCT00511355 | Organon and Co |
Contraception
|
October 2006 | Phase 3 |
NCT02403401 | Bayer |
Contraception
|
May 15, 2015 | Phase 3 |
NCT04230070 | Laboratorios Andromaco S.A. |
Bioequivalence
|
October 24, 2020 | Phase 1 |
NCT00490087 | IRCCS Burlo Garofolo |
Atypical Endometrial Polyps|Atypical Endometrial Hyperplasia
|
January 1999 | Phase 3 |
NCT00237042 | University of Washington|National Institute of Dental and Craniofacial Research (NIDCR) |
Temporomandibular Joint Disorders
|
October 2005 | Not Applicable |
NCT01990703 | University of Utah|Society of Family Planning|University of New Mexico |
Contraception
|
January 2014 | Phase 4 |
NCT04872244 | Gaziosmanpasa Research and Education Hospital |
Isthmocele|Post-menstrual Spotting Bleeding|Pelvic Pain
|
November 3, 2019 | Not Applicable |
NCT04385667 | Zagazig University |
Atypical Endometrial Hyperplasia
|
May 20, 2020 | Phase 2|Phase 3 |
NCT04194905 | Laboratorios Andromaco S.A. |
Bioequivalence
|
November 21, 2020 | Phase 1 |
NCT03249402 | Janssen-Cilag International NV |
Healthy
|
August 14, 2017 | Phase 1 |
NCT01074892 | University Hospital of North Norway|Helse Nord|Norwegian Cancer Society |
Endometrial Hyperplasia
|
May 2005 | Phase 4 |
NCT04814927 | Eastern Virginia Medical School|CONRAD|Kenya Medical Research Institute|United States Agency for International Development (USAID) |
Mucosal Inflammation|Contraceptive; Complications, Intrauterine
|
March 1, 2021 | Phase 4 |
NCT02903888 | Bayer |
Intrauterine Devices, Medicated
|
September 8, 2016 | |
NCT02556411 | University of Cagliari |
Adenomyosis|Chronic Pelvic Pain
|
June 1, 2021 | Not Applicable |
NCT01165307 | Abimbola Famuyide|Hologic, Inc.|Mayo Clinic |
Menorrhagia
|
August 2009 | Phase 4 |
NCT01501448 | IVI Madrid |
Infertility
|
January 2012 | Phase 4 |
NCT03642210 | Medicines360 |
Menorrhagia
|
January 17, 2019 | Phase 3 |
NCT00185380 | Bayer |
Contraception
|
April 2005 | Phase 2 |
NCT05343546 | Makerere University|Karolinska Institutet |
Incomplete Abortion|Intrauterine Contraception|Misoprostol
|
June 2022 | Not Applicable |
NCT00433004 | University of Pennsylvania |
Post Partum
|
February 2007 | Phase 4 |
NCT03660046 | Emory University|National Institutes of Health (NIH)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
Hormonal Contraception
|
December 7, 2018 | |
NCT01088178 | United States Naval Medical Center, Portsmouth |
Contraception
|
November 2009 | Not Applicable |
NCT02577601 | Oregon Health and Science University|Society of Family Planning |
Contraception
|
September 8, 2015 | Phase 4 |
NCT01594476 | Oregon Health and Science University|Society of Family Planning |
Contraception
|
March 2012 | Phase 4 |
NCT01570244 | Boehringer Ingelheim |
Hepatitis C, Chronic
|
April 2012 | Phase 1 |
NCT00161226 | University of Medicine and Dentistry of New Jersey|Rutgers, The State University of New Jersey |
Endometrial Cancer
|
February 2004 | |
NCT01073904 | Bayer |
Contraceptives, Postcoital
|
September 2009 | Phase 1 |
NCT04058873 | Camber Collective|Population Council|Marie Stopes International|Bill and Melinda Gates Foundation|The Children´s Investment Fund Foundation |
Pregnancy Related
|
October 1, 2019 | |
NCT01157754 | IVI Madrid |
Infertility
|
June 2009 | Not Applicable |
NCT03074045 | Bayer |
Contraception
|
March 13, 2017 | Phase 3 |
NCT00874653 | Bayer |
Menorrhagia
|
April 2008 | |
NCT02121067 | University of North Carolina, Chapel Hill|Society of Family Planning |
Contraception|Malposition of Intrauterine Contraceptive Device
|
September 2014 | Phase 4 |
NCT02846142 | Proteostasis Therapeutics, Inc. |
Healthy Volunteer
|
June 2016 | Phase 1 |
NCT00248963 | Wyeth is now a wholly owned subsidiary of Pfizer |
Oral Contraceptive
|
Phase 3 | |
NCT00393198 | Bayer |
Contraception|Menorrhagia
|
October 2006 | Phase 4 |
NCT01096498 | Bayer |
Contraception|Contraception, Postcoital
|
February 2009 | Phase 1 |
NCT00245921 | Wyeth is now a wholly owned subsidiary of Pfizer |
Contraception
|
February 2003 | Phase 3 |
NCT00909857 | Bayer |
Primary Dysmenorrhea
|
April 2009 | Phase 3 |
NCT02722421 | University of Nebraska|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Infectious Diseases Institute, Uganda|University of Liverpool|Northwestern University Feinberg School of Medicine |
HIV|Contraception
|
April 6, 2017 | Phase 2 |
NCT02599077 | Fundación Santa Fe de Bogota |
Endometriosis
|
November 2015 | Phase 2|Phase 3 |
NCT02203331 | Bayer |
Endometriosis
|
October 16, 2014 | Phase 2 |
NCT02480647 | University of Campinas, Brazil |
Endometriosis
|
May 2016 | Phase 4 |
NCT02985541 | Bayer |
Contraception
|
December 22, 2016 | Phase 3 |
NCT00302848 | Center for Epidemiology and Health Research, Germany|Bayer Healthcare Pharmaceuticals, Inc.+Bayer Schering Pharma |
Contraception
|
November 2000 | |
NCT00254189 | Wyeth is now a wholly owned subsidiary of Pfizer |
Ovulation
|
December 2002 | Phase 2 |
NCT00884260 | Bayer |
Contraception
|
April 2009 | Phase 3 |
NCT01286948 | Population Council |
Female Contraception
|
January 2011 | Phase 1 |
NCT03317795 | Shannon K. Laughlin-Tommaso|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Mayo Clinic |
Heavy Menstrual Bleeding|Menorrhagia|Uterine Fibroids
|
November 14, 2017 | Phase 4 |
NCT01254292 | Bayer |
Contraception
|
January 6, 2011 | Phase 3 |
NCT00475228 | University of Pittsburgh |
Contraceptive Usage
|
March 2007 | Phase 4 |
NCT03614494 | Dr. Hang Wun Raymond Li|The Family Planning Association of Hong Kong|The University of Hong Kong |
Emergency Contraception
|
August 20, 2018 | Phase 2|Phase 3 |
NCT02158845 | University of Sao Paulo|Fundação de Amparo à Pesquisa do Estado de São Paulo|Conselho Nacional de Desenvolvimento Científico e Tecnológico |
Endometriosis
|
February 2010 | Phase 4 |
NCT02545452 | Bayer |
Endometriosis
|
September 15, 2015 | Phase 1 |
NCT02349815 | Bayer|Karolinska Institutet, Stockholm, Sweden |
Contraception
|
January 1, 2017 | |
NCT01958684 | Bayer |
Contraception
|
October 2013 | |
NCT03305081 | Tulane University School of Medicine|Tulane University |
Contraception
|
October 22, 2014 | Not Applicable |
NCT05282940 | Laboratorios Andromaco S.A. |
Therapeutic Equivalency
|
February 26, 2022 | Phase 1 |
NCT00662454 | Oregon Health and Science University|National Institutes of Health (NIH)|Oregon Clinical and Translational Research Institute |
Contraception|Body Weight
|
January 2006 | Phase 4 |
NCT03589027 | Makerere University|University of Nebraska|University of Pittsburgh|University of Liverpool |
HIV-1-infection|Contraception
|
August 7, 2018 | Phase 2 |
NCT00685906 | AstraZeneca |
Healthy
|
April 2008 | Phase 1 |
NCT04143659 | Health Decisions|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
Healthy Women|Female Contraception
|
March 3, 2020 | Phase 1 |
NCT03104309 | Assiut University |
Adenomyosis
|
June 2015 | Not Applicable |
NCT04910711 | Botswana Harvard AIDS Institute Partnership|University of Liverpool |
Human Immunodeficiency Virus|Contraception|ART
|
October 21, 2021 | Phase 4 |
NCT00883662 | Bayer |
Contraception|Menorrhagia|Endometrial Hyperplasia|Estrogen Replacement Therapy
|
May 2009 | |
NCT00966771 | University of Utah|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Society of Family Planning |
Pregnancy
|
October 2009 | |
NCT02175030 | University of Utah |
Contraception
|
August 2016 | Phase 4 |
NCT03778359 | Taipei Veterans General Hospital, Taiwan |
Endometriosis|Adenomyosis
|
January 1, 2005 | |
NCT05093205 | Pfizer |
Healthy Adults
|
October 25, 2021 | Phase 1 |
Solid
Room temperature in continental US; may vary elsewhere.
Powder | -20°C | 3 years |
---|---|---|
4°C | 2 years | |
In solvent | -80°C | 6 months |
-20°C | 1 month |
DMSO : 100 mg/mL ( 320.05 mM ; ultrasonic and warming and heat to 60°C)
H 2 O : < 0.1 mg/mL (insoluble)
Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
---|
1 mM | 3.2005 mL | 16.0026 mL | 32.0051 mL |
5 mM | 0.6401 mL | 3.2005 mL | 6.4010 mL |
10 mM | 0.3201 mL | 1.6003 mL | 3.2005 mL |
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (8.00 mM); Clear solution