[CAS NO. 797-63-7]  Levonorgestrel

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PRODUCTS SPECIFICATIONS [797-63-7]

Catalog
HY-B0257
Brand
MCE
CAS
797-63-7

DESCRIPTION [797-63-7]

Overview

MDL-
Molecular Weight312.45
Molecular FormulaC21H28O2
SMILESO=C1CC[C@]2([H])[C@@]3([H])CC[C@]4(CC)[C@@](C#C)(O)CC[C@@]4([H])[C@]3([H])CCC2=C1

For research use only. We do not sell to patients.

Summary

Levonorgestrel is a synthetic progestogen used as an active ingredient in some hormonal contraceptives. Target: Progesterone Receptor A synthetic progestational hormone with actions similar to those of progesterone and about twice as potent as its racemic or (+-)-isomer (norgestrel). It is used for contraception, control of menstrual disorders, and treatment of endometriosis. It is usually supplied in a racemic mixture (Norgestrel, 6533-00-2). Only the levonorgestrel isomer is active. Levonorgestrel is marketed mostly as a combination oral contraceptive under several brand names such as Alesse, Triphasil, and Min-Ovral [1].


Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT04972396 Altimmune, Inc.
NASH - Nonalcoholic Steatohepatitis
October 5, 2021 Phase 1
NCT02357368 Lisa Haddad|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Emory University
HIV|Contraception
February 2015 Phase 4
NCT00360490 Bayer
Menorrhagia
July 2006 Phase 3

Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 320.05 mM ; ultrasonic and warming and heat to 60°C)

H 2 O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2005 mL 16.0026 mL 32.0051 mL
5 mM 0.6401 mL 3.2005 mL 6.4010 mL
10 mM 0.3201 mL 1.6003 mL 3.2005 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.00 mM); Clear solution

* All of the co-solvents are available by MCE.


Synonyms

18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17α)-
18,19-Dinor-17α-pregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-
(17α)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one
13-Ethyl-17α-ethynylgon-4-en-17β-ol-3-one
13β-Ethyl-17α-ethynyl-17β-hydroxygon-4-en-3-one
19-Nortestosterone, 17-ethynyl-18-methyl-
17β-Hydroxy-18-methyl-19-nor-17α-pregn-4-en-20-yn-3-one
18-Methyl-17α-ethynyl-19-nortestosterone
17α-Ethynyl-17-hydroxy-18-methylestr-4-en-3-one
17α-Ethynyl-18-methyl-19-nortestosterone
13-Ethyl-17α-ethynyl-17-hydroxygon-4-en-3-one
13-Ethyl-17-hydroxy-18,19-dinor-17α-pregn-4-en-20-yn-3-one
17α-Ethynyl-18-homo-19-nortestosterone
13-Ethyl-17-ethynyl-17β-hydroxy-4-gonen-3-one
17α-Ethynyl-13β-ethyl-3-oxo-4-estren-17β-ol
Levonorgestrel
17α-Ethynyl-13-ethyl-19-nortestosterone
Norplant
Follistrel
D-(-)-Norgestrel
Norplant 2
18-Methylnorethindrone
Microluton
(-)-Norgestrel
D-Norgestrel
Norplant II
Levonova
Jadelle
Norlevo
Mirena
Norgestrelem
Wy 5104
Microlut
Norgeston
Dexnorgestrel
Microval
Postinor 2
Lng-IUS
d-(17α)-17-Hydroxy-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one
Femilis
Femilis Slim
Sino-implant (II)
Plan B One-Step
Skyla
Jaydess