[CAS NO. 79886-50-3] 1,2,3,6-Tetragalloylglucose

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PRODUCTS SPECIFICATIONS [79886-50-3]

Catalog

HY-111832

Brand

MCE

CAS

79886-50-3

DESCRIPTION [79886-50-3]

Overview

MDL	-
Molecular Weight	788.57
Molecular Formula	C34H28O22
SMILES	O=C(C1=CC(O)=C(O)C(O)=C1)O[C@@H]2[C@H]([C@@H]([C@@H](COC(C3=CC(O)=C(O)C(O)=C3)=O)O[C@H]2OC(C4=CC(O)=C(O)C(O)=C4)=O)O)OC(C5=CC(O)=C(O)C(O)=C5)=O

For research use only. We do not sell to patients.

Summary

1,2,3,6-Tetragalloylglucose is a potent UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) inhibitor, with a K _i of 1.68 μM ^[1] .

IC50 & Target

Ki: 1.68 μM (UGT1A1) ^[1] .

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 126.81 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2681 mL	6.3406 mL	12.6812 mL
5 mM	0.2536 mL	1.2681 mL	2.5362 mL
10 mM	0.1268 mL	0.6341 mL	1.2681 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (3.17 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (3.17 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (3.17 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Park JB, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018 Oct;120:651-661.

Synonyms

β-D-Glucopyranose, 1,2,3,6-tetrakis(3,4,5-trihydroxybenzoate)

1,2,3,6-Tetra-O-galloyl-β-D-glucopyranose

β-D-Glucopyranose 1,2,3,6-tetragallate

1(β),2,3,6-Tetra-O-galloylglucose

1,2,3,6-Tetra-O-galloyl-β-D-glucose

NP 003686

Tetra-O-galloyl-β-D-glucose (TGG)

Tetra-O-galloyl-β-D-glucose

TGG