[CAS NO. 799264-47-4]  Nodinitib-1

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PRODUCTS SPECIFICATIONS [799264-47-4]

Catalog
HY-18639
Brand
MCE
CAS
799264-47-4

DESCRIPTION [799264-47-4]

Overview

MDLMFCD04322367
Molecular Weight287.34
Molecular FormulaC14H13N3O2S
SMILESNC1=NC2=CC=CC=C2N1S(=O)(C3=CC=C(C)C=C3)=O

For research use only. We do not sell to patients.


Summary

Nodinitib-1 (ML130;CID-1088438) is a NOD1 inhibitor with an IC 50 of 0.56 μM.


IC50 & Target

IC50: 0.56 μM (NOD1) [1]


In Vitro

Nodinitib-1 selectively inhibits IL-8 production induced by NOD1 ligand. Nodinitib-1 also inhibits γ-tri-DAP-induced expression of the prototypical NF-κB target gene IκBα at the mRNA level. Nodinitib-1 inhibits γ-tri-DAP-dependent activation of NF-κB (IκBα phosphorylation and degradation) and MAPK (p38 phosphorylation) signalings, without affecting Akt survival pathway. Nodinitib-1 selectively inhibits responses of primary dendritic cells to NOD1 ligand. Nodinitib-1 reduces cell surface expression of co-stimulatory molecules CD83, CD86 and HLA-DR and also inhibits expression of IL-1β, IL-6 and TNFα elicited by γ-tri-DAP (but not by LPS), without causing cytoxicity [1] . Nodinitib-1 is identified as NOD1-selective molecules from an HTS campaign involving ~290,000 compounds. Nodinitib-1 inhibits γ-tri-DAP-stimulated luciferase production in HEK 293T cells, which has endogenous NOD1 levels at submicromolar concentration as determined in a NF-κB-linked reporter assay [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL ( 69.60 mM ; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4802 mL 17.4010 mL 34.8020 mL
5 mM 0.6960 mL 3.4802 mL 6.9604 mL
10 mM 0.3480 mL 1.7401 mL 3.4802 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.70 mM); Clear solution

* All of the co-solvents are available by MCE.