MDL | MFCD04322367 |
---|---|
Molecular Weight | 287.34 |
Molecular Formula | C14H13N3O2S |
SMILES | NC1=NC2=CC=CC=C2N1S(=O)(C3=CC=C(C)C=C3)=O |
Nodinitib-1 (ML130;CID-1088438) is a NOD1 inhibitor with an IC 50 of 0.56 μM.
IC50: 0.56 μM (NOD1) [1]
Nodinitib-1 selectively inhibits IL-8 production induced by NOD1 ligand. Nodinitib-1 also inhibits γ-tri-DAP-induced expression of the prototypical NF-κB target gene IκBα at the mRNA level. Nodinitib-1 inhibits γ-tri-DAP-dependent activation of NF-κB (IκBα phosphorylation and degradation) and MAPK (p38 phosphorylation) signalings, without affecting Akt survival pathway. Nodinitib-1 selectively inhibits responses of primary dendritic cells to NOD1 ligand. Nodinitib-1 reduces cell surface expression of co-stimulatory molecules CD83, CD86 and HLA-DR and also inhibits expression of IL-1β, IL-6 and TNFα elicited by γ-tri-DAP (but not by LPS), without causing cytoxicity [1] . Nodinitib-1 is identified as NOD1-selective molecules from an HTS campaign involving ~290,000 compounds. Nodinitib-1 inhibits γ-tri-DAP-stimulated luciferase production in HEK 293T cells, which has endogenous NOD1 levels at submicromolar concentration as determined in a NF-κB-linked reporter assay [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Solid
Room temperature in continental US; may vary elsewhere.
Powder | -20°C | 3 years |
---|---|---|
4°C | 2 years | |
In solvent | -80°C | 6 months |
-20°C | 1 month |
DMSO : 20 mg/mL ( 69.60 mM ; Need ultrasonic and warming)
Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
---|
1 mM | 3.4802 mL | 17.4010 mL | 34.8020 mL |
5 mM | 0.6960 mL | 3.4802 mL | 6.9604 mL |
10 mM | 0.3480 mL | 1.7401 mL | 3.4802 mL |
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (8.70 mM); Clear solution