[CAS NO. 80-13-7] Halazone
PRODUCTS SPECIFICATIONS [80-13-7]
DESCRIPTION [80-13-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 270.09 |
| Molecular Formula | C7H5Cl2NO4S |
| SMILES | O=C(O)C1=CC=C(S(=O)(N(Cl)Cl)=O)C=C1 |
Summary
Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a K d value of 1.45 µM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water [1] [2] .
In Vitro
Halazone is chemically closely related to Chloramine-T, the nitrogen atom is linked with two instead of one chlorine atom and, certainly more important here, a methyl group is replaced by a carboxyl group. The effect of Halazone on the sodium current is studied in voltage-clamped single nerve fibers of the frog. The oxidant Halazone drastically inhibits inactivation [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
DMSO : 100 mg/mL ( 370.25 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.7025 mL | 18.5123 mL | 37.0247 mL |
| 5 mM | 0.7405 mL | 3.7025 mL | 7.4049 mL |
| 10 mM | 0.3702 mL | 1.8512 mL | 3.7025 mL |
References
- [1] M Rack, et al. Effects of Some Chemical Reagents on Sodium Current Inactivation in Myelinated Nerve Fibers of the Frog. Biophys J. 1986 Oct;50(4):557-64.
- [2] Rema Iyer, et al. Inhibition Profiling of Human Carbonic Anhydrase II by High-Throughput Screening of Structurally Diverse, Biologically Active Compounds. J Biomol Screen. 2006 Oct;11(7):782-91.
Synonyms