[CAS NO. 8048-52-0] Acriflavine
PRODUCTS SPECIFICATIONS [8048-52-0]
DESCRIPTION [8048-52-0]
Overview
| MDL | MFCD00064307 |
|---|---|
| Molecular Weight | 259.73 |
| Molecular Formula | C14H14ClN3 |
| SMILES | NC(C=C1)=CC(C1=C2)=NC3=C2C=CC(N)=C3.NC(C=C4)=CC(C4=C5)=[N+](C)C6=C5C=CC(N)=C6.[Cl-] |
4 Publications Citing Use of MCE
Summary
Acriflavine is a fluorescent dye for labeling high molecular weight RNA. It is also a topical antiseptic.
In Vitro
Acriflavine is identified as a potent inhibitor of the MCT4 that can inhibit the binding between Basigin and MCT4. Acriflavine significantly inhibits growth and self-renewal potential of several glioblastoma neurosphere lines [1] . The HIF-1 inhibitor acriflavine decreases survival and growth of CML cells. It targets stem cell potential of CML cells [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Acriflavine treatment inhibits intratumoral expression of VEGF and tumor vascularization [1] . In a murine CML model, acriflavine decreases leukemia development and reduces LSC maintenance [2] . Acriflavine retards tumor growth in a murine model of breast cancer. The combination of sunitinib with acriflavine significantly decreases vascular endothelial growth factor and TGF-β expression and reduces tumor vasculature followed by increased intratumor necrosis and apoptosis [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT03379389 | Fundação Educacional Serra dos Órgãos |
Urinary Tract Infections
|
March 31, 2018 | Phase 4 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : ≥ 25 mg/mL ( 96.25 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.8502 mL | 19.2508 mL | 38.5015 mL |
| 5 mM | 0.7700 mL | 3.8502 mL | 7.7003 mL |
| 10 mM | 0.3850 mL | 1.9251 mL | 3.8502 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 2 mg/mL (7.70 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
References
- [1] Voss DM, et al. Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression. Sci Rep. 2017 Jun 27;7(1):4292.
- [2] Cheloni G, et al. Targeting chronic myeloid leukemia stem cells with the hypoxia-inducible factor inhibitor acriflavine. Blood. 2017 Jun 2. pii: blood-2016-10-745588.
- [3] Yin T, et al. HIF-1 Dimerization Inhibitor Acriflavine Enhances Antitumor Activity of Sunitinib in Breast Cancer Model. Oncol Res. 2014;22(3):139-45.
Synonyms