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[CAS NO. 81-07-2] Saccharin
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-Y0272 |
| Brand: | MCE |
| CAS: | 81-07-2 |
Overview
| MDL | MFCD00005866 |
|---|---|
| Molecular Weight | 183.18 |
| Molecular Formula | C7H5NO3S |
| SMILES | O=C(C1=C2C=CC=C1)NS2(=O)=O |
Summary
Saccharin is an orally active, non-caloric artificial sweeteners (NAS). Saccharin has bacteriostatic and microbiome-modulating properties [1] .
In Vitro
In vitro, saccharin (0.5, 2.5, 5 mM) inhibits bacterial growth in a species-dependent manner [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
In vivo, saccharin (oral; 5 mg/kg; twice a day) intake reduces fecal bacterial load and alters microbiome composition, while the intestinal barrier is not obviously affected in male C57BL/6JRj wild type (wt) mice [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT02459535 | German Institute of Human Nutrition|Ludwig-Maximilians - University of Munich |
Pre-diabetes|Diabetes
|
March 2015 | Not Applicable |
| NCT02835859 | AdventHealth Translational Research Institute|Sanford-Burnham Medical Research Institute |
Diabetes
|
August 2014 | Not Applicable |
| NCT05229380 | Assiut University |
Eustachian Tube Dysfunction
|
February 28, 2022 | |
| NCT03708939 | Weizmann Institute of Science |
Glucose Intolerance|Glucose, Low Blood|Glucose, High Blood
|
February 19, 2017 | Not Applicable |
| NCT03032640 | AdventHealth Translational Research Institute |
Obesity
|
January 26, 2017 | Not Applicable |
| NCT01488383 | Basque Health Service |
Hyperglycemia|Hypertension
|
September 2013 | Not Applicable |
| NCT02580110 | Lund University|Anti-Diabetic Food Centre |
Healthy Subjects
|
October 2015 | Not Applicable |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 545.91 mM ; Need ultrasonic)
H 2 O : 2.63 mg/mL ( 14.36 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.4591 mL | 27.2956 mL | 54.5911 mL |
| 5 mM | 1.0918 mL | 5.4591 mL | 10.9182 mL |
| 10 mM | 0.5459 mL | 2.7296 mL | 5.4591 mL |
Synonyms
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