MDL | - |
---|---|
Molecular Weight | 330.21 |
Molecular Formula | C14H6N2O8 |
SMILES | O=C1C2=C(C(C3=C(C=CC(O)=C13)[N+]([O-])=O)=O)C([N+]([O-])=O)=CC=C2O |
1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3 , the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC 50 s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM [1] .
1,8-Dihydroxy-4,5-dinitroanthraquinone (25 μM; 12-48 h) inhibits extracellular and intracellular dengue virus growth in BHK-21 cells
[1]
.
1,8-Dihydroxy-4,5-dinitroanthraquinone (50 μM-2 mM; 90 min) inhibits NS2B/3 cleavage, and significantly and dramatically acts function at 100 μM in BHK-21 cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Room temperature in continental US; may vary elsewhere.
Please store the product under the recommended conditions in the Certificate of Analysis.
DMSO : 41.67 mg/mL ( 126.19 mM ; ultrasonic and warming and heat to 60°C)
氘代氯仿 : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
---|
1 mM | 3.0284 mL | 15.1419 mL | 30.2838 mL |
5 mM | 0.6057 mL | 3.0284 mL | 6.0568 mL |
10 mM | 0.3028 mL | 1.5142 mL | 3.0284 mL |