[CAS NO. 81-55-0]  1,8-Dihydroxy-4,5-dinitroanthraquinone

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PRODUCTS SPECIFICATIONS [81-55-0]

Catalog
HY-121138
Brand
MCE
CAS
81-55-0

DESCRIPTION [81-55-0]

Overview

MDL-
Molecular Weight330.21
Molecular FormulaC14H6N2O8
SMILESO=C1C2=C(C(C3=C(C=CC(O)=C13)[N+]([O-])=O)=O)C([N+]([O-])=O)=CC=C2O

For research use only. We do not sell to patients.

Summary

1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3 , the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC 50 s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM [1] .


In Vitro

1,8-Dihydroxy-4,5-dinitroanthraquinone (25 μM; 12-48 h) inhibits extracellular and intracellular dengue virus growth in BHK-21 cells [1] .
1,8-Dihydroxy-4,5-dinitroanthraquinone (50 μM-2 mM; 90 min) inhibits NS2B/3 cleavage, and significantly and dramatically acts function at 100 μM in BHK-21 cells [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Please store the product under the recommended conditions in the Certificate of Analysis.


Solvent & Solubility

In Vitro:

DMSO : 41.67 mg/mL ( 126.19 mM ; ultrasonic and warming and heat to 60°C)

氘代氯仿 : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0284 mL 15.1419 mL 30.2838 mL
5 mM 0.6057 mL 3.0284 mL 6.0568 mL
10 mM 0.3028 mL 1.5142 mL 3.0284 mL
* Please refer to the solubility information to select the appropriate solvent.