- Cart - 0 item(s)
- $0.00
Your shopping cart is empty!
- Chemistry
- Inhibitors
- Natural Products
- Alkaloids
- Amino acid
- Anthraquinones
- Cerebrosides
- Chalcones
- Coumarins
- Diterpenoids
- Flavonoids
- Iridoids
- Lignans
- Lipids
- Miscellaneous
- Monoterpenoids
- Other terpenes
- Phenols
- Phenylpropanoids
- Quinones
- Saccharides
- Sesquiterpenoids
- Steroids
- Tetraterpenoids
- Thiophenes
- Triterpenoids
- Xanthones
- Polyphenols
- Stibene glucosides
- Oligose
- Anthocyanins
- Miscellaneous
- Chromones
- Terpenoids
- Indoles
- Procyanidins
- Aliphatics
- Botanical Cyclopeptides
- ADCs
- Antibodies
- Multiplex IHC
- Material Science
- Others
[CAS NO. 81-55-0] 1,8-Dihydroxy-4,5-dinitroanthraquinone
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-121138 |
| Brand: | MCE |
| CAS: | 81-55-0 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 330.21 |
| Molecular Formula | C14H6N2O8 |
| SMILES | O=C1C2=C(C(C3=C(C=CC(O)=C13)[N+]([O-])=O)=O)C([N+]([O-])=O)=CC=C2O |
Summary
1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3 , the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC 50 s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM [1] .
In Vitro
1,8-Dihydroxy-4,5-dinitroanthraquinone (25 μM; 12-48 h) inhibits extracellular and intracellular dengue virus growth in BHK-21 cells
[1]
.
1,8-Dihydroxy-4,5-dinitroanthraquinone (50 μM-2 mM; 90 min) inhibits NS2B/3 cleavage, and significantly and dramatically acts function at 100 μM in BHK-21 cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
DMSO : 41.67 mg/mL ( 126.19 mM ; ultrasonic and warming and heat to 60°C)
氘代氯仿 : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.0284 mL | 15.1419 mL | 30.2838 mL |
| 5 mM | 0.6057 mL | 3.0284 mL | 6.0568 mL |
| 10 mM | 0.3028 mL | 1.5142 mL | 3.0284 mL |
Arctom is a premier supply platform offering over 600K unique items of Building Blocks, Bioactive Molecules, Natural Products, ADC PEG Linkers, Antibodies, and other Research Chemicals for global pharmaceutical, biotech, university, and industrial customers. We accelerate your research by providing better and faster purchasing experience & services.