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Catalog: | HY-B0165A |
Brand: | MCE |
CAS: | 81131-70-6 |
MDL | MFCD00887601 |
---|---|
Molecular Weight | 446.51 |
Molecular Formula | C23H35NaO7 |
SMILES | O[C@@H](C[C@@H](O)CC(O[Na])=O)CC[C@@H]([C@H](C=C1)C)[C@@](C1=C[C@@H](O)C2)([H])[C@H]2OC([C@@H](C)CC)=O |
Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC 50 of 5.6 μM.
HMG-CoA reductase [1] .
Pravastatin (CS-514) is a member of the drug class of statins, used in combination with diet, exercise, and weight-loss for lowering cholesterol and preventing cardiovascular disease [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
NCT Number | Sponsor | Condition | Start Date | Phase |
---|---|---|---|---|
NCT00456365 | University of Colorado, Denver|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
Polycystic Kidney, Autosomal Dominant
|
November 2006 | Phase 3 |
NCT04190433 | Mayo Clinic |
Lymphoma
|
September 1, 2020 | Phase 2 |
NCT00829309 | Teva Pharmaceuticals USA |
Healthy
|
March 2005 | Phase 1 |
NCT02992548 | Dong-A University |
Chronic Kidney Disease
|
September 2015 | Phase 4 |
NCT00433498 | University College, London |
Lung Cancer
|
January 2007 | Phase 3 |
NCT00305201 | Pontificia Universidad Catolica de Chile|Bristol-Myers Squibb |
Kawasaki Disease
|
April 2006 | Phase 2 |
NCT01057654 | University Hospital, Bonn |
Hypercholesterolemia|Hyperlipoproteinemia
|
January 1996 | Phase 3 |
NCT00571194 | Arkansas Children´s Hospital Research Institute |
End Stage Renal Disease
|
September 2007 | Phase 1 |
NCT00005010 | National Institute of Allergy and Infectious Diseases (NIAID) |
End-Stage Renal Disease|Chronic Allograft Nephropathy
|
Phase 3 | |
NCT01441908 | MaiHealth Inc |
Dyslipidemia
|
June 2011 | Not Applicable |
NCT01903694 | Centre Hospitalier Universitaire Dijon |
Child-Pugh A Hepatocellular Carcinoma
|
March 2010 | Phase 3 |
NCT00166036 | Emory University |
Diabetes Mellitus|Metabolic Syndrome X|Hypercholesterolemia
|
September 2004 | Phase 2 |
NCT00688922 | Osaka Acute Coronary Insufficiency Study Group |
Acute Myocardial Infarction
|
July 2008 | Phase 4 |
NCT03801733 | Akebia Therapeutics |
Drug Interaction Potentiation
|
June 17, 2018 | Phase 1 |
NCT00631189 | AstraZeneca |
Type IIa and IIb Hypercholesterolaemia
|
October 2007 | Phase 4 |
NCT00330980 | University of California, San Diego|National Heart, Lung, and Blood Institute (NHLBI) |
Dyslipidemias
|
April 2000 | Phase 4 |
NCT01557075 | Yonsei University |
Drug-eluting Stent (DES)
|
July 2010 | Phase 4 |
NCT01845428 | University of North Carolina, Chapel Hill|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
Nephrotic Syndrome|Hyperlipidemia
|
May 2012 | Phase 1 |
NCT00701285 | JW Pharmaceutical |
Chronic Heart Failure
|
July 2008 | Phase 4 |
NCT03944512 | The George Washington University Biostatistics Center|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Heart, Lung, and Blood Institute (NHLBI) |
Preeclampsia|Obstetric Labor Complications|Hypertension in Pregnancy
|
July 17, 2019 | Phase 3 |
NCT00303277 | Seattle Institute for Biomedical and Clinical Research |
Alzheimer´s Disease|Aging
|
August 2002 | Phase 4 |
NCT00697203 | Hoffmann-La Roche |
Dyslipidemia
|
July 2005 | Phase 2 |
NCT00384618 | Amsterdam UMC, location VUmc|Medical Research Foundation, The Netherlands|Bristol-Myers Squibb |
Chronic Kidney Disease
|
May 2001 | Phase 4 |
NCT00916747 | Boston Children´s Hospital|Schering-Plough|Merck Sharp & Dohme LLC|Eiger BioPharmaceuticals |
Progeria
|
August 2009 | Phase 2 |
NCT00382460 | Bristol-Myers Squibb |
Actue Coronary Syndromes
|
November 2000 | Phase 4 |
NCT00982189 | Hennepin Healthcare Research Institute|American Heart Association |
HIV Infection|Cardiovascular Disease Risk
|
September 2009 | Not Applicable |
NCT00665717 | Radboud University Medical Center|Merck Sharp & Dohme LLC |
HIV Infections
|
May 2008 | Phase 1 |
NCT00221104 | Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan|Ministry of Health, Labour and Welfare, Japan|Hiroshima University |
Ischemic Stroke
|
March 1, 2004 | Phase 3 |
NCT00054938 | Brigham and Women´s Hospital|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) |
Systemic Lupus Erythematosus|Lupus
|
March 2003 | Phase 2 |
NCT01146106 | Dr. Reddy´s Laboratories Limited |
Healthy
|
December 2002 | Phase 1 |
NCT04284657 | University of Southern California |
Autosomal Dominant Polycystic Kidney Disease
|
January 30, 2019 | Phase 2 |
NCT02518516 | Canadian Network for Observational Drug Effect Studies, CNODES|Drug Safety and Effectiveness Network, Canada|Canadian Institutes of Health Research (CIHR) |
Hypercholesterolemia
|
January 2011 | |
NCT02079974 | Dr. Robert F. Casper|Toronto Centre for Advanced Reproductive Technology |
Endometriosis
|
July 2014 | Not Applicable |
NCT05107063 | Daiichi Sankyo, Inc.|Daiichi Sankyo Korea Co., Ltd. |
Dyslipidemia Associated With Type II Diabetes Mellitus
|
January 20, 2016 | |
NCT01717586 | The University of Texas Medical Branch, Galveston|University of Pittsburgh|Northwestern University|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
Preeclampsia
|
August 2012 | Phase 1 |
NCT01816997 | Taipei Veterans General Hospital, Taiwan |
Diabetes
|
January 2012 | Phase 4 |
NCT00107523 | Fred Hutchinson Cancer Center |
Leukemia
|
January 2005 | Phase 1 |
NCT02360826 | Children´s Mercy Hospital Kansas City|American Heart Association |
Drug Distribution
|
June 17, 2014 | Phase 1 |
NCT00467831 | National Human Genome Research Institute (NHGRI)|National Institutes of Health Clinical Center (CC) |
Hermansky-Pudlak Syndrome (HPS)|Pulmonary Fibrosis|Oculocutaneous Albinism|Platelet Storage Pool Deficiency|Metabolic Disease
|
April 2007 | Phase 1|Phase 2 |
NCT00654537 | AstraZeneca |
Hypercholesterolemia
|
April 2001 | Phase 3 |
NCT00459745 | Shionogi|Integrium|Shionogi Inc. |
Combined Hyperlipidemia
|
April 2007 | Phase 3 |
NCT02621957 | Genentech, Inc. |
Breast Cancer
|
December 2015 | Phase 1 |
NCT00702130 | University of Thessaly |
Ventilator Associated Pneumonia
|
June 2008 | Early Phase 1 |
NCT00834379 | Teva Pharmaceuticals USA |
Healthy
|
September 2000 | Phase 1 |
NCT00830258 | Teva Pharmaceuticals USA |
Healthy
|
April 2005 | Phase 1 |
NCT04425902 | ViiV Healthcare |
HIV Infections
|
December 16, 2020 | Phase 1 |
NCT00639223 | University of Pennsylvania|Chestnut Hill Health System |
Hypercholesterolemia|Statin-Associated Myopathy
|
January 2008 | Phase 2 |
NCT01146093 | Dr. Reddy´s Laboratories Limited |
Healthy
|
November 2002 | Phase 1 |
NCT03219372 | Cedars-Sinai Medical Center|National Institutes of Health (NIH)|National Cancer Institute (NCI) |
Hepatocellular Carcinoma|Liver Cirrhoses
|
September 27, 2018 | Phase 2 |
NCT02456844 | Bristol-Myers Squibb |
Rheumatoid Arthritis
|
May 2015 | Phase 1 |
NCT03456102 | Johns Hopkins University |
Tuberculosis
|
March 9, 2020 | Phase 2 |
NCT01301066 | Kowa Research Institute, Inc.|Kowa Pharmaceuticals America, Inc.|Eli Lilly and Company |
Dyslipidemia
|
December 2010 | Phase 4 |
NCT02229773 | Boehringer Ingelheim |
Healthy
|
January 2000 | Phase 1 |
NCT00688896 | Akros Pharma Inc. |
Type II Hyperlipidemia
|
June 2002 | Phase 2 |
NCT01831232 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Chronic Myelomonocytic Leukemia|de Novo Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Neoplasm, Unclassifiable|Refractory Anemia With Excess Blasts|Untreated Adult Acute Myeloid Leukemia
|
May 2013 | Not Applicable |
NCT01342887 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Recurrent Adult Acute Myeloid Leukemia
|
April 2011 | Phase 1|Phase 2 |
NCT01857921 | Yonsei University |
Coronary Artery
|
December 2010 | Not Applicable |
NCT01268202 | Gustave Roussy, Cancer Campus, Grand Paris|Ministry of Health, France |
Fibrosis
|
December 17, 2010 | Phase 2 |
NCT03273413 | University of Colorado, Denver |
ADPKD|Autosomal Dominant Polycystic Kidney
|
August 31, 2017 | Phase 4 |
NCT00650221 | Mylan Pharmaceuticals Inc|Genpharm ULC|MylanPharma |
Therapeutic Equivalency
|
June 2003 | Phase 1 |
NCT01254461 | AstraZeneca |
Drug Interaction
|
February 2011 | Phase 1 |
NCT00006412 | National Institute of Allergy and Infectious Diseases (NIAID) |
HIV Infections|Lipodystrophy
|
Phase 3 | |
NCT00549926 | Yokohama City University Medical Center |
Coronary Disease|Hypercholesterolemia
|
October 2007 | Phase 4 |
NCT00599625 | University of Virginia|American College of Gastroenterology |
Crohn´s Disease
|
October 2004 | Not Applicable |
NCT00227500 | Kirby Institute|The University of New South Wales|National Heart, Lung, and Blood Institute (NHLBI)|Garvan Institute of Medical Research|St Vincent´s Hospital, Sydney |
HIV Infections|Lipid Metabolism|Glucose Metabolism|Metabolic Abnormality|Lipodystrophy|Cardiovascular Disease
|
July 2001 | Phase 4 |
NCT03648970 | Universitas Airlangga |
Pre-Eclampsia
|
March 1, 2018 | Phase 2 |
NCT02266485 | Boehringer Ingelheim |
Healthy
|
July 1998 | Phase 1 |
NCT00039663 | National Institutes of Health Clinical Center (CC) |
HIV Infections
|
May 2002 | Phase 1 |
NCT03073018 | University Medical Center Groningen|Dutch Kidney Foundation|Netherlands Heart Foundation |
Microalbuminuria|Cardiovascular Diseases|Renal Disease
|
April 1998 | Phase 3 |
NCT00000542 | National Heart, Lung, and Blood Institute (NHLBI) |
Cardiovascular Diseases|Coronary Disease|Diabetes Mellitus|Heart Diseases|Hypercholesterolemia|Hypertension|Myocardial Infarction|Myocardial Ischemia|Heart Failure
|
August 1993 | Phase 3 |
NCT04719481 | Peking University Third Hospital |
Postmenopausal Osteoporosis
|
November 2021 | Phase 4 |
NCT03882177 | National Institute of Allergy and Infectious Diseases (NIAID) |
Tuberculosis|Pulmonary Tuberculosis
|
February 21, 2020 | Phase 2 |
NCT00362206 | Solvay Pharmaceuticals |
Hyperlipidemia
|
September 2006 | Phase 3 |
NCT01958489 | Eli Lilly and Company |
Healthy Volunteers
|
October 2013 | Phase 1 |
NCT02431013 | Ajou University School of Medicine |
Dyslipidemias|Peripheral Artery Disease
|
April 2015 | Phase 1 |
NCT00000941 | National Institute of Allergy and Infectious Diseases (NIAID) |
HIV Infections
|
Phase 1 | |
NCT02518503 | Canadian Network for Observational Drug Effect Studies, CNODES|Drug Safety and Effectiveness Network, Canada|Canadian Institutes of Health Research (CIHR) |
Diabetes Mellitus, Type 2|Cardiovascular Disease
|
July 2012 | |
NCT00000461 | National Heart, Lung, and Blood Institute (NHLBI) |
Cardiovascular Diseases|Coronary Disease|Heart Diseases|Myocardial Ischemia
|
December 1986 | Phase 2 |
NCT01856374 | Yonsei University |
Multi-vessel Diseases, Angina
|
August 2011 | Phase 4 |
NCT01075555 | Federation Francophone de Cancerologie Digestive|Centre Hospitalier Universitaire Dijon |
Liver Cancer
|
February 2010 | Phase 3 |
NCT00738296 | Hospital Universitario 12 de Octubre|Merck Sharp & Dohme LLC|Hospital Regional 1o de Octubre |
Cardiovascular Diseases
|
April 2005 | Phase 4 |
NCT01602913 | GlaxoSmithKline |
Depression, Postpartum
|
December 2011 | |
NCT03510715 | Sanofi|Regeneron Pharmaceuticals |
Hypercholesterolemia
|
August 31, 2018 | Phase 3 |
NCT00731016 | Assistance Publique Hopitaux De Marseille |
Hutchinson-Gilford Progeria Syndrome
|
October 2008 | Phase 2 |
NCT00214604 | AstraZeneca |
Hyperlipoproteinemia Type III
|
February 2005 | Phase 3 |
NCT00117494 | French National Agency for Research on AIDS and Viral Hepatitis |
Hyperlipidemia|HIV Infections
|
October 2005 | Phase 4 |
NCT00840177 | Southwest Oncology Group|National Cancer Institute (NCI) |
Leukemia
|
August 2009 | Phase 2 |
NCT00177580 | University of Pittsburgh|Stanley Medical Research Institute |
Schizophrenia|Schizoaffective Disorder
|
July 2003 | Phase 4 |
NCT04640571 | University of Maryland, Baltimore |
Bile Salt Export Pump (BSEP) Transporter|Polysorbate 80
|
April 1, 2021 | Phase 4 |
NCT00257686 | Kowa Research Europe |
Hypercholesterolemia or Combined Dyslipidemia
|
September 2005 | Phase 3 |
NCT02754739 | Samsung Medical Center|Daiichi Sankyo Korea Co., Ltd. |
Diabetes Mellitus|Prediabetic State
|
April 15, 2014 | Phase 4 |
NCT01173939 | Positive Trial Group |
Hypercholesterolemia|Type 2 Diabetes|Hypertension
|
July 2010 | Not Applicable |
NCT04356209 | Institut du Cancer de Montpellier - Val d´Aurelle |
Breast Cancer
|
September 28, 2020 | Phase 2 |
NCT01082588 | Massachusetts General Hospital|Stanley Medical Research Institute|North Suffolk Mental Health Association |
Schizophrenia|Schizoaffective Disorders|Schizophreniform Disorders
|
June 2010 | Phase 4 |
NCT01515813 | AIDS Clinical Trials Group|National Institute of Allergy and Infectious Diseases (NIAID) |
HIV-1 Infection
|
November 2011 | Phase 2 |
NCT00200655 | Nantes University Hospital |
Relapsing-remitting Multiple Sclerosis
|
December 2004 | Phase 3 |
NCT00879034 | Boston Children´s Hospital|Dana-Farber Cancer Institute|Brigham and Women´s Hospital|Schering-Plough |
Progeria|Hutchinson-Gilford Syndrome
|
March 2009 | Phase 2 |
NCT03510884 | Sanofi|Regeneron Pharmaceuticals |
Hypercholesterolaemia
|
May 31, 2018 | Phase 3 |
NCT01788254 | Matthias Schwab|University Hospital Tuebingen |
Genotype-related Drug Metabolism
|
January 2012 | Phase 1 |
NCT01845194 | Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH |
Drug Biotransformation|Membrane Transport
|
December 2009 | Phase 1 |
NCT01502904 | Yonsei University |
Stable Angina or Acute Coronary Syndrome Considered for Percutaneous Coronary Intervention With Dyslipidemia or Hypertension
|
July 2010 | Phase 4 |
NCT02841774 | Matthew Feinstein|Northwestern University |
HIV Infection|Coronary Heart Disease
|
November 2016 | Phase 2 |
NCT00221754 | University Hospital, Bordeaux|Ministry of Health, France |
HIV Infection|Hypercholesterolemia
|
March 2003 | Phase 2 |
NCT00529178 | Bristol-Myers Squibb |
Hypercholesterolemia
|
December 2002 | Phase 4 |
NCT00132717 | Organon and Co |
Hypercholesterolemia
|
January 1, 2005 | Phase 3 |
NCT04608344 | Gilead Sciences|Galapagos NV |
Rheumatoid Arthritis
|
November 4, 2020 | Phase 1 |
NCT00738972 | Fundación Lindavista del Corazón AC |
Hypertension
|
January 2008 | Phase 3 |
NCT00005117 | National Center for Research Resources (NCRR) |
Heart Diseases
|
Not Applicable | |
NCT00017758 | National Institute of Allergy and Infectious Diseases (NIAID) |
HIV Infections|HIV Seronegativity|Lipodystrophy
|
Phase 1 | |
NCT05524246 | Children´s Hospital Medical Center, Cincinnati |
Hematopoietic Stem Cell Transplant (HSCT)|Endothelial Injury
|
November 2022 | Phase 1 |
NCT02484261 | Reuven Schore|Millennium Pharmaceuticals, Inc.|Hyundai Hope On Wheels|Children´s National Research Institute |
Leukemia
|
May 2015 | Phase 1 |
NCT00843661 | Ospedale di Circolo - Fondazione Macchi|Merck Sharp & Dohme LLC |
HIV|Hyperlipidemia|HIV Infections
|
March 2009 | Phase 4 |
NCT00000539 | National Heart, Lung, and Blood Institute (NHLBI) |
Arterial Occlusive Diseases|Cardiovascular Diseases|Heart Diseases|Vascular Diseases|Diabetes Mellitus
|
September 1992 | Phase 3 |
NCT00755352 | Daiichi Sankyo, Inc. |
Hypercholesterolemia
|
November 2002 | Phase 4 |
NCT01418729 | Hospital Donostia|INSTITUTO BIODONOSTIA |
Advanced Hepatocarcinoma
|
September 2011 | Phase 2 |
NCT00834847 | Teva Pharmaceuticals USA |
Healthy
|
August 2000 | Phase 1 |
NCT03131973 | Bristol-Myers Squibb |
Rheumatoid Arthritis
|
May 13, 2017 | Phase 1 |
NCT00380939 | Pfizer |
Coronary Arteriosclerosis
|
April 1999 | Phase 4 |
NCT01038154 | Hospital Donostia |
Esophageal Cancer|Stomach Cancer
|
November 2009 | Phase 4 |
NCT01256476 | Kowa Research Institute, Inc. |
Primary Dyslipidemia|Mixed Dyslipidemia
|
October 2010 | Phase 4 |
NCT02155530 | Yonsei University |
Coronary Artery Disease
|
June 2014 | Not Applicable |
NCT01857843 | Yonsei University |
Acute Coronary Syndrome
|
November 2009 | Phase 4 |
NCT02871687 | Brigham and Women´s Hospital |
Healthy Subjects
|
April 2016 | Phase 1 |
NCT00630734 | University of Colorado, Denver|Tibotec Therapeutics, a Division of Ortho Biotech Products, L.P., USA |
HIV Infections|Hyperlipidemia
|
February 2008 | Phase 4 |
NCT01497483 | University of California, San Francisco|National Institute of General Medical Sciences (NIGMS) |
Healthy
|
December 2011 | Phase 1 |
NCT01872845 | Yonsei University |
Coronary Artery Occlusive Disease
|
June 12, 2013 | Not Applicable |
NCT01357486 | University Hospital, Bordeaux|Federation Francophone de Cancerologie Digestive|UNICANCER |
Hepatocellular Carcinoma|CHILD B
|
November 14, 2011 | Phase 2 |
NCT02547402 | Complexa, Inc. |
Acute Kidney Injury
|
December 2015 | Phase 1 |
NCT00648544 | Mylan Pharmaceuticals Inc|Genpharm ULC|MylanPharma |
Therapeutic Equivalency
|
July 2003 | Phase 1 |
Solid
Penicillium Citrinum
Room temperature in continental US; may vary elsewhere.
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
DMSO : 100 mg/mL ( 223.96 mM ; Need ultrasonic)
H 2 O : ≥ 50 mg/mL ( 111.98 mM )
* "≥" means soluble, but saturation unknown.
Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
---|
1 mM | 2.2396 mL | 11.1980 mL | 22.3959 mL |
5 mM | 0.4479 mL | 2.2396 mL | 4.4792 mL |
10 mM | 0.2240 mL | 1.1198 mL | 2.2396 mL |
Add each solvent one by one: PBS
Solubility: 100 mg/mL (223.96 mM); Clear solution; Need ultrasonic
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution
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