[CAS NO. 821768-06-3] JNJ-17203212

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PRODUCTS SPECIFICATIONS [821768-06-3]

Catalog

HY-100129

Brand

MCE

CAS

821768-06-3

DESCRIPTION [821768-06-3]

Overview

MDL	MFCD12828764
Molecular Weight	419.32
Molecular Formula	C17H15F6N5O
SMILES	O=C(N1CCN(C2=NC=CC=C2C(F)(F)F)CC1)NC3=NC=C(C(F)(F)F)C=C3

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]EBioMedicine. 2022 Oct;84:104258.

Summary

JNJ-17203212 is a selective, potent and competitive TRPV1 antagonist. JNJ-17203212 is developed for researching pain management, such as migraine ^[1] ^[2] .

IC50 & Target

TRPV1

In Vitro

JNJ-17203212 (0.5 μM) potently inhibits imperatorin-induced TRPV1 activation (Ca ²⁺ increases) in TRPV1-expressing HEK cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

JNJ-17203212 (0.3 mg/kg ; i.v.) dose-dependently reduces inflammatory soup (IS)-induced the immediate early gene c-fos expression ^[2] .
JNJ-17203212 completely blocks capsaicin-induced CGRP (the neurotransmitter calcitonin gene-related peptide) release in a dose-dependent manner ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (260-300 g) ^[2]
Dosage:	0.3 mg/kg
Administration:	Intravenous injection
Result:	Had a dose-dependent effect on the elevated c-fos expression that occurred after intracisternal injection of IS.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 238.48 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3848 mL	11.9241 mL	23.8481 mL
5 mM	0.4770 mL	2.3848 mL	4.7696 mL
10 mM	0.2385 mL	1.1924 mL	2.3848 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.75 mg/mL (6.56 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.75 mg/mL (6.56 mM); Clear solution

* All of the co-solvents are available by MCE.