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[CAS NO. 82196-88-1] Chrysomycin A
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-126771 |
| Brand: | MCE |
| CAS: | 82196-88-1 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 508.52 |
| Molecular Formula | C28H28O9 |
| SMILES | O=C1C2=CC(C=C)=CC(OC)=C2C3=CC(OC)=C4C(O)=CC=C([C@H]5[C@@H]([C@]([C@H]([C@@H](C)O5)O)(C)O)O)C4=C3O1 |
Summary
Chrysomycin A (Chr-A), an antibiotic , can be obtained from Streptomyces . Chrysomycin A exhibits antitumor and anti-tuberculous and MRSA activities. As for glioblastoma, Chrysomycin A inhibits the proliferation, migration, and invasion of cancer cells through the Akt/GSK-3β/β-catenin signaling pathway [1] .
In Vitro
Chrysomycin A (0.2-1.8 μM; 48 h) has anti-glioblastoma efficacy, and inhibits cell viability in U251 and U87-MG human glioblastoma, as well as migration and invasion
[1]
.
Chrysomycin A (0.2-1.8 μM; 48 h) inhibits Akt/GSK-3β/β-Catenin signaling pathway in U251 and U87-MG cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | U251 and U87-MG human glioblastoma |
| Concentration: | 0.2, 0.4 and 0.8 μM for U251; 0.2, 0.6 and 1.8 μM for U87-MG |
| Incubation Time: | 48 hours |
| Result: | Inhibited U251 and U87-MG with 0.475 μM and 1.77 μM, respectively. |
Western Blot Analysis [1]
| Cell Line: | U251 and U87-MG human glioblastoma |
| Concentration: | 0.2, 0.4 and 0.8 μM for U251; 0.2, 0.6 and 1.8 μM for U87-MG |
| Incubation Time: | 48 hours |
| Result: |
Significantly downregulated the expression of slug and MMP2.
Significantly decreased the protein expression of PI3K-p85, p-PI3K-p85, Akt and p-Akt, as well as c-Myc, cyclin D1. |
Source
marine-derived strain Streptomyces sp. 891
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
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