[CAS NO. 823830-85-9] M1002
PRODUCTS SPECIFICATIONS [823830-85-9]
DESCRIPTION [823830-85-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 394.29 |
| Molecular Formula | C15H8F6N2O2S |
| SMILES | O=S1(N=C(C2=C1C=CC=C2)NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=O |
Summary
M1002 is a hypoxia-inducible factor-2 ( HIF-2 ) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors [1] .
In Vitro
M1002 (10 μM; 24 h) enhances the expression of HIF-2 target genes with great efficacy
[1]
.
M1002 (5 μM; 24 h) treatment shows synergy with prolyl hydroxylase domain (PHD) inhibitors
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
RT-PCR [1]
| Cell Line: | 786-O cells |
| Concentration: | 10 μM |
| Incubation Time: | 24 hours |
| Result: | Showed clear agonistic effects on the expression of HIF-2 target genes in 786-O cells as compared with the control. |
RT-PCR [1]
| Cell Line: | Hep3B cells |
| Concentration: | 5 μM |
| Incubation Time: | 24 hours |
| Result: | Elevated the expression of EPO and NDRG1 by co-treatment of M1002 together with PHD inhibitors, compared with M1002 alone treatment. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |