[CAS NO. 82385-42-0] Saccharin sodium hydrate

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PRODUCTS SPECIFICATIONS [82385-42-0]

Catalog

HY-B1390B

Brand

MCE

CAS

82385-42-0

DESCRIPTION [82385-42-0]

Overview

MDL	-
Molecular Weight	-
Molecular Formula	C7H5NO3S.xH2O.Na
SMILES	O=C(C1=C2C=CC=C1)N([Na])S2(=O)=O.O.[x]

For research use only. We do not sell to patients.

Summary

Saccharin sodium hydrate is an orally active, non-caloric artificial sweeteners (NAS). Saccharin sodium hydrate has bacteriostatic and microbiome-modulating properties ^[1] .

In Vitro

In vitro, Saccharin sodium hydrate (0.5, 2.5, 5 mM) inhibits bacterial growth in a species-dependent manner ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In vivo, Saccharin sodium hydrate (oral; 5 mg/kg; twice a day) intake reduces fecal bacterial load and alters microbiome composition, while the intestinal barrier is not obviously affected in male C57BL/6JRj wild type (wt) mice ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT02580110	Lund University\|Anti-Diabetic Food Centre	Healthy Subjects	October 2015	Not Applicable
NCT02835859	AdventHealth Translational Research Institute\|Sanford-Burnham Medical Research Institute	Diabetes	August 2014	Not Applicable
NCT01488383	Basque Health Service	Hyperglycemia\|Hypertension	September 2013	Not Applicable
NCT05229380	Assiut University	Eustachian Tube Dysfunction	February 28, 2022
NCT02459535	German Institute of Human Nutrition\|Ludwig-Maximilians - University of Munich	Pre-diabetes\|Diabetes	March 2015	Not Applicable
NCT03708939	Weizmann Institute of Science	Glucose Intolerance\|Glucose, Low Blood\|Glucose, High Blood	February 19, 2017	Not Applicable
NCT03032640	AdventHealth Translational Research Institute	Obesity	January 26, 2017	Not Applicable

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (Need ultrasonic)

H ₂ O : 83.33 mg/mL (Need ultrasonic)

In Vivo:

1.

Add each solvent one by one: PBS

Solubility: 100 mg/mL (Infinity mM); Clear solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (Infinity mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (Infinity mM); Clear solution
4.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (Infinity mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Sünderhauf A, et al. Saccharin Supplementation Inhibits Bacterial Growth and Reduces Experimental Colitis in Mice. Nutrients. 2020 Apr 17;12(4). pii: E1122.

Synonyms

1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, sodium salt, hydrate (1:1:?)

1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, sodium salt, hydrate

Saccharin sodium salt hydrate