[CAS NO. 827001-82-1] 5J-4
PRODUCTS SPECIFICATIONS [827001-82-1]
DESCRIPTION [827001-82-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 312.34 |
| Molecular Formula | C16H12N2O3S |
| SMILES | O=C(C1=CC=CO1)NC(NC2=CC=CC3=C2C=CC(O)=C3)=S |
Summary
5J-4 is a potent CRAC inhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation [1] .
In Vivo
5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt
[1]
.
5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) reduces the symptoms and delayed the onset of EAE
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | C57BL/6 mice (MOG35-55 peptide-immunized mice) [1] |
| Dosage: | 2 m/kg |
| Administration: | I.p., every alternate day for 30 days |
| Result: | Dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of infiltrated mononuclear cell into the CNS, and significantly decreased the population of infiltrated CD4+ population. |
Appearance
Powder
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |