[CAS NO. 827591-02-6] GSK983
PRODUCTS SPECIFICATIONS [827591-02-6]
DESCRIPTION [827591-02-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 325.79 |
| Molecular Formula | C18H16ClN3O |
| SMILES | O=C(C1=NC=CC=C1)N[C@H]2C3=C(CCC2)C(C=C(C=C4)Cl)=C4N3 |
Summary
In Vitro
GSK983 (0-10000 nM; 2 h) inhibits replication of adenovirus-5 (Ad-5) in primary human fibroblasts (HFF) and polyoma virus SV40 in Vero cells with the median effect concentration (K) of 21 nM, 7.5 nM; and maximum inhibition (I max) of 99%, 88%, respectively
[1]
.
GSK983 (0-10000 nM; 72 h) inhibits the growth of cell lines immortalized by viral infection with the median effect concentration (K) of 16, 14, 7.5 nM for IM9 (EBV), B-LCL 5/2/1 (EBV), MT4 (HTLV1) cells, respectively
[1]
.
GSK983 (10, 100 nM; 24, 48 h) induces the expression of interferon-stimulated genes in W12, HKC cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
RT-PCR [1]
| Cell Line: | W12, HKC cells |
| Concentration: | 10, 100 nM |
| Incubation Time: | 24, 48 h |
| Result: | Induced the expression of interferon-stimulated genes in infected and immortalized cells, increased the gene expression of CSF2, IFIT1 (ISG56), IL6, ISG15, OAS1, OAS2, OASL and TNFSF10 (TRAIL). |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.